Evaluation of antinociceptive effect of Xanthium strumarium Linn. leaves extract in Swiss albino mice

Atul S. Akarte, Vishwas C. Bhagat, Pradeep T. Deshmukh, Chandrakant Disle

Abstract


The aim of this study was to explore the probable antinociceptive effect of an ethanolic extract of Xanthium strumarium L. leaves in Swiss albino mice by using models of Eddy’s hot plate test, tail immersion test and acetic acid induce writhing test. Swiss albino mice were treated i.p. with saline water (control), test group treated with 50, 100, 200 and 400 mg/kg extract per oral, standard group treated with pentazocin 3 mg/kg. The results are expressed as the mean ± SEM. and statistically analyzed using one-way analysis of variance (ANOVA) followed by a Student-Newman-keuls test for multiple comparisons using Graph Pad Instant statistical program. Values of p< 0.05 were considered to be significant. The ethanolic extract showed the dose-dependent antinociceptive activity in Eddy’s hot plate test, tail immersion test and acetic acid induce writhing test at time intervals 15, 30, 60 and 120 min.
Key words: Antinociceptive activity, ethanolic extract, Xanthium strumarium Linn

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DOI: http://dx.doi.org/10.22377/ijgp.v3i2.73

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