Effect of Baliospermum montanum root extract on phagocytosis by human neutrophils

Raju Ratan Wadekar, Sagar Vijay Agrawal, Kunal Mahesh Tewari, Rohan Dilip Shinde, Shirin Mate, Kalpana Patil

Abstract


To study the eff ect of alcohol extract of roots of Baliospermum montanum on neutrophil phagocytic function. Diff erent concentrations (25,50,100 mg/ml) of the extract of Baliospermum montanum roots were subjected to study its eff ect on diff erent in-vitro models for phagocytosis such as neutrophil locomotion, chemotaxis, immunostimulant activity on killed Candida albicans and qualitative nitroblue tetrazolium test using human neutrophils. Th is preliminary study revealed that Baliospermum montanum extract stimulated the chemotactic, phagocytic and intracellular killing potency of human neutrophils at the diff erent concentrations. From the results
obtained it can be observed that the alcohol extract of Baliospermum montanum stimulates cell-mediated immune system by increasing neutrophil function.
Key words: Baliospermum montanum, immonostimulant, nitroblue tetrazolium test, phagocytosis

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DOI: http://dx.doi.org/10.22377/ijgp.v2i2.41

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