Effect of Baliospermum montanum root extract on phagocytosis by human neutrophils

Raju Ratan Wadekar, Sagar Vijay Agrawal, Kunal Mahesh Tewari, Rohan Dilip Shinde, Shirin Mate, Kalpana Patil


To study the eff ect of alcohol extract of roots of Baliospermum montanum on neutrophil phagocytic function. Th e diff erent concentration of (25,50,100 mg/ml) extract of roots of Baliospermum montanum was subjected to study its eff ect on diff erent in vitro methods of phagocytosis such as neutrophil locomotion, chemotaxis, immunostimulant activity of phagocytosis of killed Candida albicans and qualitative nitroblue tetrazolium test using human neutrophils. Th is preliminary study revealed that Baliospermum montanum extract
has stimulated, chemotactic, phagocytic and intracellular killing potency of human neutrophils at diff erent concentrations. From the results obtained, it can be observed that the alcohol extract of Baliospermum montanum stimulates cell-mediated immune system by increasing neutrophil function.
Key words: Immunostimulant, Baliospermum montanum, nitroblue tetrazolium test, phagocytosis

Full Text:



Chatt rjee A, Treatise on Indian Medicinal Plants, Vol III, CSIR

New Delhi, 1994, 24.

Fulzele SV, Satt urwar PM, Joshi SB, Study of Immunomodulatory

activity of Haridradi Ghrita in rats, Indian Journal of Pharmacology,

, 2003, Suppl 1, 51-54.

Gulati K, Debnath PK, Bhatt acharya SK, Immunomodulatory Indian

Medicinal Plants, Journal of Natural Remedies, 2, 2002, 121-131.

Kulkarni SK, Handbook of Experimental Pharmacology, Delhi,

Vallabh Prakashan, 1999, 179-180.

Mallurwar VR, Joharapurkar AJ, Durgakar KJ, Studies on

Immunomodulatory Activity of Mucuna prurien, Indian Journal

of Pharmaceutical Education Research, 40, 2006, Suppl 3, 205.

Patwardhan B, Kalbag D, Patki PS, Search of Immunomodulatory

Agents, A Review. Indian Drugs, 28, 1991, 249.

Variers PS, Arya Vaidya Sala. Indian Medicinal Plant-A

compendium of 500 species. Vol I orient Longman Ltd; Madras,

, 240.

Wilkinson PC, Neutrophil leucocyte function test In: Thomas RA

(Ed.), Techniques in Clinical Immunology, 2nd ed. London,

Blackwell ScientiÞ c Publication, 1981, 273-293.

Ziauddin M, Phansalkar N, Patki P, Diwanay S, Patwardhan B,

Studies on the Immunomodulatory eff ects of Ashwagandha,

Journal of. Ethanopharmacology, 50, 1996, Suppl 2, 69-76.

DOI: https://doi.org/10.22377/ijgp.v2i1.396


  • There are currently no refbacks.