Evaluation of anti-inflammatory activity of Gymnema sylvestre leaves extract in rats

Jitender K. Malik, F.V. Manvi, K.R. Alagawadi, M. Noolvi


Th e aqueous extract of Gymnema sylvestre leaves was investigated for evaluation of anti-infl ammatory activity in rats at a dose 200,300 and 500 mg/kg in carrageenin-induced paw oedema and cotton pellet method. Results of in vivo activity led to the conclusion that the aqueousextract of Gymnema sylvestre showed predominantly signifi cant activity, which is comparable to the standard drug Phenybutazone.
Key words: Anti-infl ammatory, aqueous extract, Gymnema sylvestre leaves

Full Text:



Arya Vaidya Shala. Indian Medicinal Plants: A Compendium of

species, Vol. 3. Madras: Orient Longman Ltd; 1997. p. 107-9.

Kokate CK. Pharmacognosy. 12th ed. Mumbai: Nirali Prakashan;

p. 210-1.

Agarwal SK, Lakshmi. Chemistry and medicinal uses of Gymnema

sylvestre (Gur-Mar) leaves: A review. Indian Drug 2000;37:354-60.

Turner RA. Screening methods of Pharmacology. New York:

Academic Press; 1965. p. 22-41.

Winter CA, Risely EA, Nuss GW. Carregeenin induced oedema

in hind paw of the rat as assay for anti-inß ammatory drugs. Exp

Biol Med 1962;111:544.

Winter CA, Poster CC. Eff ect of alteration in side chain upon antiinfammatory

and liver glycogen activities in hydrocortisone ester.

J Am Pharmacol 1957;46:515.

Woodson RF. Statistical method for analysis of biochemical data.

New York: Wiely; 1987. p. 315-88.

DOI: https://doi.org/10.22377/ijgp.v2i2.42


  • There are currently no refbacks.