Comparative hepatoprotective activity of Liv-52 and livomyn against carbon tetrachloride-induced hepatic injury in rats

V.D. Sapakal, R.V. Ghadge, R.S. Adnaik, N.S. Naikwade, C.S. Magdum

Abstract


Liver disease is one of the serious health problems. Herbs play a major role in the management of various liver disorders. Th e present study was conducted to compare the hepatoprotective activity of two marketed formulations, Liv-52 and Livomyn. Th e formulations showed signifi cant hepatoprotective eff ect by reducing elevated serum enzyme levels such as glutamate pyruvate transaminase (SGPT), glutamate oxaloacetate transaminase (SGOT), bilirubin content (direct and total) and total protein. Th ese biochemical observations
were supplemented by weight and histopathological examination of liver sections. Various pathological changes such as steatosis,
centrilobular necrosis and vacuolization observed in rats treated only with CCl4, but the groups treated with the CCl4, and hepatoprotective formulations were producted to a moderete extent from such pathological changes. Silymarin was used for positive control. It was concluded from study that Liv-52 has shown more signifi cant hepatoprotective activity against c CCL4-induced hepatotoxicity in rats in comparison to Livomyn.
Key words: Carbon tetrachloride, hepatoprotective activity, Liv-52, livomyn, silymarin

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DOI: http://dx.doi.org/10.22377/ijgp.v2i2.33

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