Evaluation of anti-nociceptive activity of Cissus quadrangularis on albino mice

G.S. Mate, N.S. Naikwade, C.S. Magdum, A.A. Chowki, S.B. Patil

Abstract


Th roughout the history, man has used several forms of therapy for relief of pain; among them, medicinal herbs have gained popularity because of its wide use and less side eff ects. Cissus quadrangularis, for example, is a commonly used folklore medicine in India to hasten the fracture healing process; in Cameroon, the whole plant is used for the treatment of oral dehydration, while in Africa and Asia, the leaves, stems and roots are utilized for the treatment of various ailments. Th e plant extract were prepared by using chloroform
and distilled water in proportion (20:80), macerated for 72 h with occasional stirring and concentrated under dry vacuum. Th e extract of Cissus quadrangularis was examined for centrally acting analgesics by using the hot plate method, formalin test and acetic acidinduced writhing method for peripherally acting analgesics. Th e doses administered were 250 mg/kg and 350 mg/kg. Th e animal that administered both the doses showed signifi cant analgesic activity. Th e animal that administered a dose of 350 mg/kg has shown the maximum analgesic activity which is comparable to the standard.
Key words: Analgesic, Cissus quadrangularis, formalin, writhing

Full Text:

PDF

References


Ahmadiani A, Fereidoni M, Semnanian S, Kamalinejad M, Saremi S.

Antinociceptive and anti-inß ammatory eff ects of Sambucus ebulus

rhizome extract in rats. J Ethnopharmacol 1998;61:229-35.

Almeida RN, Navarro DS, Barbosa-Filho JM. Plants with central

analgesic activity. Phytomedicine 2001;8:310-22.

Nadkarni AK. In: Indian Materia Medica. 3rd ed. Mumbai: Popular

Book Depot; 1954. p. 1284.

Chopra SS, Patel MR, Gupta LP, Datta IC. Studies on Cissus

quadrangularis in experimental fracture repair: Eff ect on chemical

parameters in blood. Indian J Med Res 1975;63:824-8.

Kirtikar KR, Basu BD. Cissus quadrangularis Indian medicinal

plants. Blatter E, Calus JE, Mhasker KS, editors. Allahabad;

p. 604.

Asolkar LV, Kakkar KK, Chakre OJ. Supplement to glossary of

Indian medicinal plants with active principles. New Delhi, India:

Publication and Information Directorate (CSIR): 1999.

Udupa KN, Arnikar HJ, Singh LM. Experimental studies of the use

of Cissus quadrangularis in healing of fractures, II. Indian J Med

Sci 1961;15:551-7.

Udupa KN, Prasad G. Biomechanical and calcium-45 studies on

the eff ect of Cissus quadrangularis in fracture repair. lndian J Med

Res 1964;52:480-7.

Deka DK, et al. Indian J Pharmacol 1994;26:44.

OECD Guidelines for Testing Chemicals, Guidelines 423, acute

oral toxicity: Acute toxic class method. Paris: 1996.

Singh SP, et al. Indian J Pharmacol 1984;79:162.

Sen SP. Proceedings of the Indian medicinal plants. Curr Sci

;35:317.

Ramaamurthy B, Seshadri T. Active constituents (oxo steroids) of

Cissus quadrangularis. Proc Indian Acad Sci 1939;9:121.

Eddy NB, Lembach D. Synthesis, anti-inß ammatory and analgesic

activity of pyrido[2,1-b]quinazoline derivatives. J Pharma Exp Ther

;707:385.

Stai HY, et al. Anti-inß ammatory and analgesic activities of extract

from roots of Angelica pubescens. Planta Medica 1995;61:1.

Schowb M, Dubost MC. Entendre la douleur. Pharmapost, RC

Montargis. France: 1984. p. 99.

Kulkarni SK. Hand Book of Experimental Pharmacology. Delhi:

Vallabh Prakashan; 1999. p. 117.

Rang HP, Dale MM, Ritt er JM, Moore PK. pharmacology. 5th ed.

New Delhi: Churchill Livingstone Publ; 2005. p. 562.

Murray CW, Porreca F, Cowan A. Methodological reÞ nements

to the mouse paw formalin test. An animal model of tonic pain.

J Pharmacol Methods 1988;20:175-86.

Elisabetsky E, Amador TA, Albuquerque RR, Nunes DS, Carvalho

Ado C. Analgesic activity of Psychotria colorata (Willd. ex R. & S.)

Muell. Arg. alkaloids. J Ethnopharmacol 1995;48:77-83.

Pal S, Sen T, Chaudhuri AK. Neuropsychopharmacological proÞ le

of the methanolic fraction of Bryophyllum pinnatum leaf extract.

J Pharma Pharmacol 1999;51:313-8.




DOI: http://dx.doi.org/10.22377/ijgp.v2i2.44

Refbacks

  • There are currently no refbacks.