Evaluation of anti-nociceptive activity of Cissus quadrangularis on albino mice

G.S. Mate, N.S. Naikwade, C.S. Magdum, A.A. Chowki, S.B. Patil


Th roughout the history, man has used several forms of therapy for relief of pain; among them, medicinal herbs have gained popularity because of its wide use and less side eff ects. Cissus quadrangularis, for example, is a commonly used folklore medicine in India to hasten the fracture healing process; in Cameroon, the whole plant is used for the treatment of oral dehydration, while in Africa and Asia, the leaves, stems and roots are utilized for the treatment of various ailments. Th e plant extract were prepared by using chloroform
and distilled water in proportion (20:80), macerated for 72 h with occasional stirring and concentrated under dry vacuum. Th e extract of Cissus quadrangularis was examined for centrally acting analgesics by using the hot plate method, formalin test and acetic acidinduced writhing method for peripherally acting analgesics. Th e doses administered were 250 mg/kg and 350 mg/kg. Th e animal that administered both the doses showed signifi cant analgesic activity. Th e animal that administered a dose of 350 mg/kg has shown the maximum analgesic activity which is comparable to the standard.
Key words: Analgesic, Cissus quadrangularis, formalin, writhing

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DOI: https://doi.org/10.22377/ijgp.v2i2.44


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