Effect of Bauhinia purpurea Linn. on Alloxan-induced diabetic rats and isolated Frog’s heart

K.S. Muralikrishna, K.P. Latha, C.S. Shreedhara, V.P. Vaidya, A.M. Krupanidhi

Abstract


In the present study, the ethanolic extract and a purifi ed fraction-1of stem of Bauhinia purpurea Linn. (BP) were investigated for anti-diabetic activity and adrenergic property. Th e anti-diabetic activity of the extract and fraction-1 was compared with standard insulin and adrenergic property was compared with sympathetic agonists and its blocker. Th e results demonstrated that the percentage of changes of FBS at the dose of 100 mg/kg. (i.p.) of ethanolic extract of BP and fraction-1 were statistically signifi cant (p < 0.001). Th e same fraction exhibited excellent adrenergic activity (10 mg/ml). Th is was further confi rmed as its action was blocked by an adrenergic β2-blocker (propranolol).
Key words: Adrenaline, anti-diabetic activity, alloxan, Bauhinia purpurea Linn., insulin, propranolol

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DOI: http://dx.doi.org/10.22377/ijgp.v2i2.34

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