Turmeric (Curcuma longa L.): A promising spice for phytochemical and pharmacological activities

Deepika Yadav, Shiv Kumar Yadav, Roop Krishen Khar, Mohammad Mujeeb, Mohammad Akhtar


Turmeric (Curcuma longa) is a small rhizomatous perennial herb belonging to Zingiberaceae family originating from South‑Eastern
Asia, most probably from India. The plant produces fleshy rhizomes of bright yellow to orange colour in its root system, which are the source of the commercially available spice turmeric. In the form of root powder, turmeric is used for its flavouring properties as a spice, food preservative and food‑colouring agent. Turmeric has a long history of use in Ayurvedic medicine as it is credited with a variety of important beneficial properties. Turmeric constituents include the three curcuminoids: Curcumin (diferuloylmethane; the primary constituent and the one responsible for its vibrant yellow colour), demethoxycurcumin and bisdemethoxycurcumin, as well as volatile oils (tumerone, atlantone and zingiberone), sugars, proteins and resins. Several studies using the modern techniques have authenticated turmeric used as anti‑inflammatory, antimicrobial, anti‑fertility, anticancer, anti‑diabetic, antioxidant, hypolipidemic, anti‑venom, anti hepato‑toxic, nephroprotective, anticoagulant, etc., Most importantly, the plant has shown to possess anti HIV
activity which could be of great value to combat AIDS particularly in third world countries. In this present work, we make an overview of the phytochemistry and pharmacological activities of turmeric, showing its importance.
Key words: Curcuma longa, phytochemistry, turmeric

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Ravindran PN, Nirmal Babu K, Sivaraman K. Turmeric. The golden

spice of life. In: Turmeric. The Genus Curcuma. Boca Raton, FL,

USA: CRC Press; 2007. p. 1‑14.

Chattopadhyay I, Biswas K, Bandyopadhyay U, Banerjee RK.

Turmeric and curcumin: Biological actions and medicinal

applications. Curr Sci India 2004;87:44‑53.

Eigner D, Scholz D. Ferula asa‑foetida and Curcuma longa in

traditional medical treatment and diet in Nepal. J Ethnopharmacol


Govindarajan VS. Turmeric--chemistry, technology, and quality.

Crit Rev Food Sci Nutr 1980;12:199-301.

Ammon HP, Anazodo MI, Safayhi H, Dhawan BN, Srimal RC.

Curcumin: A potent inhibitor of leukotriene B4 formation in rat

peritoneal polymorphonuclear neutrophils (PMNL) Planta Med


Ammon HP, Wahl MA. Pharmacology of Curcuma longa. Planta

Med 1991;57:1‑7.

Bernard GT, Esteban P, Christopher JS. Turmerones: Isolation

from turmeric and their structure determination. Chem Commun


Scientific Correspondence. Major constituents in leaf essential oils

of Curcuma longa L. and Curcuma aromatica Salisb. Curr Sci India


Rao CV, Rivenson A, Simi B, Reddy BS. Chemoprevention of colon

carcinogenesis by dietary curcumin, a naturally occurring plant

phenolic compound. Cancer Res 1995;55:259‑66.

Perkins S, Verschoyle RD, Hill K, Parveen I, Threadgill MD,

Sharma RA, et al. Chemopreventive efficacy and pharmacokinetics

of curcumin in the min/+ mouse, a model of familial adenomatous

polyposis. Cancer Epidemiol Biomarkers Prev 2002;11:


Shpitz B, Giladi N, Sagiv E, Lev‑Ari S, Liberman E, Kazanov D,

et al. Celecoxib and curcumin additively inhibit the growth of

colorectal cancer in a rat model. Digestion 2006;74:140‑4.

Kwon Y, Magnuson BA. Age‑related differential responses to

curcumin‑induced apoptosis during the initiation of colon cancer

in rats. Food Chem Toxicol 2009;47:377‑85.

Zeng Y, Qiu F, Takahashi K, Liang J, Qu G, Yao X. New

sesquiterpenes and calebin derivatives from Curcuma longa. Chem

Pharm Bull (Tokyo) 2007;55:940‑3.

Gupta SK, Lather A, Jaiswal V. Phytochemistry of Curcuma

longa‑An overview. J Pharm Biomed Sci 2010;4: 1‑9.

Srimal RC, Dhawan BN. Pharmacology of diferuloyl

methane (curcumin), a non‑steroidal anti‑inflammatory agent.

J Pharm Pharmacol 1973;25:447‑52.

Ukil A, Maity S, Karmakar S, Datta N, Vedasiromoni JR, Das PK.

Curcumin, the major component of food flavour turmeric, reduces

mucosal injury in trinitrobenzene sulphonic acid‑induced colitis.

Br J Pharmacol 2003;139:209‑18.

Funk JL, Oyarzo JN, Frye JB, Chen G, Lantz RC, Jolad SD, et al.

Turmeric extracts containing curcuminoids prevent experimental

rheumatoid arthritis. J Nat Prod 2006;69:351‑5.

Gukovsky I, Reyes CN, Vaquero EC, Gukovskaya AS,

Pandol SJ. Curcumin ameliorates ethanol and nonethanol

experimental pancreatitis. Am J Physiol Gastrointest Liver Physiol


Chan MM, Huang HI, Fenton MR, Fong D. In vivo inhibition

of nitric oxide synthase gene expression by curcumin, a cancer

preventive natural product with anti‑inflammatory properties.

Biochem Pharmacol 1998;55:1955‑62.

Dujic J, Kippenberger S, Ramirez‑Bosca A, Diaz‑Alperi J,

Bereiter‑Hahn J, Kaufmann R, et al. Curcumin in combination with

visible light inhibits tumor growth in a xenograft tumor model.

Int J Cancer 2009;124:1422‑8.

Huang MT, Lou YR, Xie JG, Ma W, Lu YP, Yen P, et al. Effect

of dietary curcumin and dibenzoylmethane on formation of

,12‑dimethylbenz a anthracene‑induced mammary tumors

and lymphomas/leukemias in Sencar mice. Carcinogenesis


How to cite this article: Yadav D, Yadav SK, Khar RK, Mujeeb M, Akhtar

M. Turmeric (Curcuma longa L.): A promising spice for phytochemical and

pharmacological activities. Int J Green Pharm 2013;7:85-9.

Source of Support: Nil, Conflict of Interest: None declared.

Tomita M, Kawakami H, Uchihara JN, Okudaira T, Masuda M,

Takasu N, et al. Curcumin (diferuloylmethane) inhibits

constitutive active NF‑kappaB, leading to suppression of cell

growth of human T‑cell leukemia virus type I‑infected T‑cell

lines and primary adult T‑cell leukemia cells. Int J Cancer


Motterlini R, Foresti R, Bassi R, Green CJ. Curcumin, an antioxidant

and anti‑inflammatory agent, induces heme oxygenase‑1 and

protects endothelial cells against oxidative stress. Free Radic Biol

Med 2000;28:1303‑12.

DOI: http://dx.doi.org/10.22377/ijgp.v7i2.302


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