Evaluation of antinociceptive activity of Ajuga bracteosa wall ex benth

Raghunath Singh Khatri, Mumtaz Ahmad, Gagandeep Pal, Vrish Dhwaj Ashwlayan


Objective: The present study was aimed to investigate the in vivo anti‑nociceptive activity of Neelkanthi (whole plant) and to
support its traditional use. Materials and Methods: Methanolic extract of plant Ajuga bracteosa (ABE) was investigated for its
anti‑nociceptive activity in hot‑plate method, tail flick method and formalin induced hind paw licking test in mice. Three doses of the extract (ABE ‑ 250 mg/kg, 500 mg/kg and 750 mg/kg, i.p.) were used in the study and codeine (5 mg/kg, i.p.) was used as standard.
Results: ABE (500 mg/kg and 750 mg/kg, i.p.) significantly (P < 0.05) increased the reaction time in both hot plate method and tail flick method. ABE also showed significant decrease in the paw licking response in formalin induced hind paw licking test in mice.
Conclusions: ABE at the dose of 500 mg/kg and 750 mg/kg showed potent anti‑nociceptive activity on comparison with the standard drug and supported its traditional use as analgesic.
Key words: Anti‑nociceptive, codeine, formalin, tail‑flick

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DOI: https://doi.org/10.22377/ijgp.v7i1.301


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