Memory enhancing effect of various polar and non-polar extracts of Plumbago zeylanica Linn. roots

Abstract

Aim: The main aim of our study is to evaluate the memory enhancing effect of various extracts of Plumbago zeylanica Linn. roots in suitable animals models. Materials and Methods: Roots were extracted by successive solvent methods by petroleum ether, chloroform, methanol, butanol, and finally water. All the extracts were subjected to phytochemical screening for the presence of various active phytoconstituents. All the extracts were evaluated by Morris water test, and brain acetylcholinesterase level was measured. Result: The chloroform extract showed the presence of alkaloids. Among all the extracts, chloroform extract significantly decreased the escape latency and increased the time spent in target quadrant. Chloroform extract significantly lowers the level of acetylcholinesterase level as compared to all other extracts. Conclusion: Among all the extracts, chloroform extract significantly increased the learning and memory in Morris water test and lowered the brain acetylcholinesterase level.