Diuretic activity of extracts of Mimusops elengi Linn. bark

Basavaraj C. Koti, Purnima Ashok

Abstract


In the present study, petroleum ether, chloroform, and alcoholic extracts of Mimusops elengi Linn. bark (200 mg/kg body weight, p. o.) were tested for diuretic activity. The animals were grouped into five of six animals each. The first group received only 0.9% sodium chloride solution (25 ml/kg body weight) and the second group received the standard drug furosemide (20 mg/kg body weight) in 0.9% sodium chloride solution. Rest of the three groups received each of extracts viz. petroleum ether, chloroform, and alcohol of M. elengi bark in a dose of 200 mg/kg body weight suspended in 0.9% sodium chloride solution (p. o). After oral administration, urine was collected and volume was recorded at 5 hours. The highest diuretic activity was presented by the alcoholic extract. Diuretic
activity was not observed in chloroform and petroleum ether extracts. We observed a potent diuretic and electrolyte excretion activity in alcoholic extract of M. elengi bark.
Key words: Diuretic activity, furosemide, Mimusops elengi

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References


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DOI: https://doi.org/10.22377/ijgp.v4i2.126

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