A preliminary study on hypolipidemic effect of aqueous leaf extract of Clerodendron glandulosum.Coleb

R. N. Jadeja, M. C. Thounaojam, Ansarullah Ansarullah, R. V. Devkar, A. V. Ramachandran

Abstract


Aqueous extract of Clerodendron glandulosum. Coleb (CG) (400 mg/kg/day) was orally administered to rats rendered hyperlipidemic chronically (by feeding high-fat diet; HL) to assess its possible lipid-lowering potential. The hyperlipidemic rats were administered CG extract by oral gavage from 30-90 days along with high fat diet. Plasma lipid profile was monitored on 30th, 60th and 90th days to assess the effect of CG extract. Observations revealed a decrement in body weight (9.6%), plasma TC (15.63%), TG (42.99%), PL (13.91%),
LDL-C (81.36%) and VLDL-C (43%) along with an increase in HDL-C (52.84%) at 90 days (after 60 days of CG extract feeding)
compared to high levels at 30 days. Fecal lipid analysis revealed high content of TC, TG and PL in HL 1 CG group. Lipid‑lowering
property of the CG extract in chronic hyperlipidemic rats validates its use traditionally as a part of folklore medicine in North-eastern India, though there is no scientific evaluation to date.
Key words: Cholesterol, Clerodendron glandulosum. Coleb, hyperlipidemia, lipoproteins

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DOI: http://dx.doi.org/10.22377/ijgp.v3i4.102

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