Randomised placebo controlled study on Sarasvata choorna in generalised anxiety disorder

Kshama Gupta, Prasad Mamidi, Anup B. Thakar

Abstract


Background: Generalised anxiety disorder (GAD) is characterised by a pattern of frequent, persistent worry and anxiety, which is out of proportion to the impact of the event or circumstance that is the focus of the worry. GAD is associated with muscle tension, trembling, twitching, feeling shaky and muscle aches or soreness. Many individuals with GAD also experience somatic symptoms like sweating, nausea and diarrhoea. Epidemiological studies reveal that the prevalence rate of GAD in India is 5.8%. Objective: The main objective of the present study was to evaluate the efficacy of Sarasvata choorna in the management of GAD. Materials and Methods: In this study, a total of 114 patients with GAD satisfying the Diagnostic and Statistical Manual of Mental Disorders – Text Revision (DSM IV – TR) diagnostic criteria were selected and randomly divided; of these, 102 patients completed the course of treatment. In trial group,
Sarasvata choorna and in control group, placebo (wheat powder) was given with the dose of 1 g thrice a day (i.e. 3 g/day) along with madhu (honey) and ghrita (cow’s ghee) orally for 60 days. Fifteen days of follow up period was kept after treatment. Two assessments were done before and after treatment. Criterion of assessment was based on the scoring of Hamilton Anxiety Rating Scale (HAM‑A). Paired and unpaired ‘t’‑test was used for statistical analysis. Results and Conclusion: In trial group (n = 51), 51.1% improvement and in control group (n = 51), 47.67% of improvement was observed with the significance of (P < 0.001). No statistically significant difference (P > 0.05) was found in between the two groups. Sarasvata choorna did not provide better relief compared with placebo.
Key words: Generalised anxiety disorder, placebo, Sarasvata choorna

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References


Wittchen HU. Generalized anxiety disorder: Prevalence, burden,

and cost to society. Depress Anxiety 2002;16:162‑71.

Canadian Psychiatric Association. Clinical practice guidelines:

Management of anxiety disorders. Can J Psychiatry 2006;51:9‑91S.

Gorini A, Riva G. The potential of virtual reality as anxiety

management tool: A randomized controlled study in a sample of

patients affected by generalized anxiety disorder. Trials 2008;9:25.

Kulkarni R, Girish KJ, Kumar A. Nootropic herbs (Medhya

Rasayana) in Ayurveda: An update. Pharmacogn Rev 2012;6:147‑53.

Govinda das sen. Bhaishajya ratnavali. With the commentaries

of ‘Vidyotini’ hindi vyakhya by Shastri A. In: Shastri R. Unmada

Chikitsa Adhyaya. 24/26‑29. 19th ed.. Varanasi: Chaukhamba

Sanskrit Sansthana; 2008. p. 513.

Gupta K, Ashok BK, Ravishankar B, Thakar AB. Anti‑anxiety and

anti‑depressant activities of Sarasvata choorna in experimental

animals. Ayu 2011;32:590‑3.

American Psychiatric Association. Diagnostic and Statistical

Manual of Mental Disorders‑Text Revision (DSM‑IV‑TR). Anxiety

disorders – Generalized Anxiety Disorder. 4th ed. New Delhi:

Jaypee Publications; 2000. p. 476.

Randomization.com [homepage on the Internet]. 100 subjects

randomized in to two blocks, to reproduce the plan use the seed

and 14 subjects randomized in to two blocks, to reproduce

the plan use the seed 21101. Available from: http://www.

randomization.com/[Last retrieved on 2009 Jan 02, 2010 Jan 07].

Hamilton M. The assessment of anxiety states by rating. Br J Med

Psychol 1959;32:50‑5.

Brown TA. The nature of generalized anxiety disorder and

pathological worry: Current evidence and conceptual models.

Can J Psychiatry 1997;42:817‑25.

Davey GCL, Wells A. Worry and its psychological disorders:

Theory, assessment and treatment. Hoboken, NJ, USA: John Wiley

and Sons, Ltd; 2006. p. 385‑8.

Sadock BJ, Sadock VA. Comprehensive textbook of psychiatry.

Anxiety Disorders: Clinical Features. 8th ed. Philadelphia:

Lippincott Williams and Wilkins; 2005. p. 1777.

Rickels K, Pollack MH, Sheehan DV, Haskins JT Efficacy of

extended‑release venlafaxine in nondepressed outpatients with

generalized anxiety disorder. Am J Psychiatry 2000;157:968‑74.

Mennin DS, Turk CL, Heimberg RG, Carmin CN. Regulation of

emotion in generalized anxiety disorder. HFJ 2002;8:63.

Corona G, Petrone L, Mannucci E, Magini A, Lotti F, Ricca V, et al.

Assessment of the relational factor in male patients consulting for

sexual dysfunctions: The concepts of couple sexual dysfunction.

J Androl 2006;27:795‑801.

Mishra LC. Scientific basis for Ayurvedic therapies. Psychiatric

disorders – Anxiety disorders. Washington: CRC Press; 2004.

p. 448.

Sharma PC, Yelne MB, Dennis TJ. Database on medicinal plants

used in Ayurveda. Reprint ed. Vol. 1‑8. New Delhi: CCRAS

Publication; 2005.

Oken BS. Placebo effects: Clinical aspects and neurobiology. Brain

;131:2812‑23.




DOI: http://dx.doi.org/10.22377/ijgp.v8i4.418

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