In silico modeling, synthesis, and in vitroanti-tubercular activity of some novelthiazolidine-2-one derivatives

Abstract

Tuberculosis, caused by Mycobacterium tuberculosis, remains a major global health concern despite available treatments and vaccination. The pathogen’s ability to evade immune responses and establish latent infection complicates disease control. Objectives: The study investigates in silico design, synthesis, physicochemical characterization, and in vitro anti-tubercular activity of some novel Thiazolidine-2-one derivatives that were synthesized by a conventional method. Methods: All the newly synthesized derivatives were characterized by determining their melting point, retention factor from thin-layer chromatography, and spectral methods (infrared, 1H nuclear magnetic resonance spectroscopy, 13C nuclear magnetic resonance spectroscopy, and mass spectroscopy) and evaluated for their in vitro anti-tubercular activity. Results: Thiazolidine-2-one derivatives have been synthesized and characterized using physical and spectral methods. In vitro anti-tubercular study revealed that compounds 1c and 2c have shown promising anti-tubercular activity at 50 ?g/mL and 100 ?g/ mL. Compounds 1a and 2a have shown moderate anti-tubercular activity at 100 ?g/mL against the H37Rv strain. Conclusion: From the results, it can be concluded that compounds 1c and 2c showed more potent in vitro anti-tubercular activity