Dermoprotective efficacy of ursolic acid an overview

Abstract

Ursolic acid (UA) is a natural terpene compound, found in many plants, and has drawn attention for its potential
benefits in skin protection. This review delves into its mechanisms of action. It highlights its antioxidant properties,
which help combat oxidative stress in skin cells by neutralizing harmful reactive oxygen species. Ursolic acid also
exhibits anti-inflammatory effects by targeting pathways involved in inflammation, such as nuclear factor-kappa
B and Mitogen-activated protein kinase. In addition, it shows promise in preventing photoaging by inhibiting
matrix metalloproteinases and promoting collagen synthesis, thus preserving skin elasticity and reducing wrinkles
caused by ultraviolet radiation. Moreover, it aids in wound healing by stimulating keratinocyte proliferation,
angiogenesis, and extracellular matrix remodeling. Recent studies suggest its antimicrobial properties, which could
be beneficial in treating infectious skin diseases. Furthermore, it may regulate skin lipid metabolism, enhancing
moisturization and skin barrier function. Overall, the diverse protective actions of ursolic acid make it a promising
candidate for developing new treatments for various skin issues, from inflammation to wound healing and aging.
Further research is needed to fully understand its mechanisms and clinical effectiveness in dermatology.