Cardioprotective effects of Butea monosperma (Lam.) following myocardial infarction in rats with isoproterenolinduced heart failure

Abstract

Objective: The objective of this study was to evaluate the protective role of Butea monosperma (Lam.) aqueous
extract (BMAE) on the various risk factors of ischemic heart disease. Methods: The male albino rats of Wistar
strain were randomly divided and treated with BMAE (200, 400, and 600 mg/kg per oral) or normal saline or
vitamin E for 30 days with concomitant subcutaneous injection of isoproterenol (ISO 85 mg/kg) on 29th and
30th day, at 24 h intervals. The effects of BMAE on cardiac marker enzymes, namely, creatine kinase (CK) and
lactate dehydrogenase (LDH), antioxidant enzymes, namely, superoxide dismutase (SOD), catalase (CAT), reduced
glutathione (GSH), and glutathione peroxidase (GPx), and lipid profile, namely, cholesterol (CH), triglyceride
(TG), low-density lipoproteins (LDL), and high-density lipoproteins (HDL), along with histopathological changes
were accessed in ISO-induced myocardial infarction (MI) in male Wistar rats. Results: ISO-treated rats exhibited
a significant (p˂0.05) enhancement in the levels of CH, TG, LDL, CK, and LDH; also, there was a significant
decrease in SOD and CAT, GSH, and GPx activity when compared to normal control rats. However, pretreatment
with BMAE 600 mg/kg per oral for 30 days significantly (p˂0.05) reversed the effects of ISO when compared to
ISO-treated rats which were further endorsed by the histopathological studies. Conclusion: The current findings
suggest that BMAE mitigates the cardiotoxic effects of ISO and may be of worth in the treatment of MI.