Anti‑inflammatory and antinociceptive activities of H. schulli seed extracts

Dayanand M. Kannur, Mukta P. Paranjpe, Prerana P. Dongre, Subhash T. Kumbhar, Kishanchand R. Khandelwal


Background: H. schulli aerial parts have been attributed with anti‑inflammatory and analgesic properties in the folklore medicine. There has been no systematic study carried out till date to substantiate the anti‑inflammatory and analgesic properties of the seeds of H. schulli. Aim: The aim of our study was to carry out the evaluation of the anti‑inflammatory and analgesic properties of the seeds of H. schulli. Materials and Methods: In this study, H. schulli seeds were extracted with ethanol and hexane and carrageenan‑induced paw oedema, Eddy’s hot plate test, tail immersion method were used to screen the anti‑inflammatory and analgesic actions of the seeds.
Statistical Analysis: The results were statistically interpreted using Student’s “t” test. Results: The results obtained clearly indicate
that H. schulli seed extracts have the ability to decrease the carrageenan‑induced foot paw oedema. The seed extracts enhanced the pain threshold capacity in both the models, thereby producing analgesia. Conclusions: We can thereby conclude that H. schulli seed
extracts posses’ anti‑inflammatory and antinociceptive activity.
Key words: Anti‑inflammatory, antinociceptive, H. schulli, tail flick

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