Screening of roots of Baliospermum montanum for hepatoprotective activity against paracetamol induced liver damage in albino rats

Raju Ratan Wadekar, Radhika Sachin Supale, Kunal Mahesh Tewari, Kalpana S. Patil, Sunil Satyappa Jalalpure

Abstract


Th e objective of the present investigation was to study hepatoprotective activity of alcohol, chloroform and aqueous extract of roots of Baliospermum montanum paracetamol induced liver damage model in rats. Liver damage in rats was produced by paracetamol (2 g/kg, po) in tween 80. Alcohol, chloroform, aqueous extracts of roots of the plant was administered to rats daily for seven days. Th e biochemical parameters were investigated. Histopathological changes in liver were studied. Concurrently silymarin was used as
standard hepatoprotective agent. Th e results indicated that biochemical changes produced by paracetamol were restored to normal by alcohol, chloroform and aqueous extracts. Th e alcohol and aqueous extract of roots of Baliospermum montanum showed signifi cant hepatoprotective eff ect whereas chloroform extract showed moderate hepatoprotective activity against paracetamol induced liver damage model in rats.
Key words: Baliospermum montanum, hepoatoprotective, paracetamol, silymarin

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DOI: http://dx.doi.org/10.22377/ijgp.v2i4.10

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