Antihyperglycemic activity of the ethanolic seed extract of Vernonia anthelminticum willd

A. Karthikeyan, G. Siva, S. P. Sujitha, D. A. P. Rex2

Abstract


Th e investigation was carried out to study the eff ects of Vernonia anthelminticum Willd seed extract on blood glucose level. Th eantihyperglycemic effi cacy of the ethanolic extract of the seed was evaluated in normal, glucose and alloxan induced diabetic rats. The extract exhibited signifi cant hypoglycemic activity in all three animal models when compared with the control group. Th e activity was also comparable to that of the eff ect produced by a standard antidiabetic agent gliclazide, 25 mg/kg (p.o.). Th e results also indicated dose dependent eff ect. Th e hypoglycemia and antihyperglycaemia produced by the extract may be due to increased uptake of glucose
at tissue level or increase in pancreatic beta-cell function or due to inhibition of intestinal absorption of glucose. Th e study indicated that the ethanolic extract is a potential antidiabetic agent and lends scientifi c support for its else’s in folk medicine.
Key words: Alloxan, antidiabetic, blood glucose, gliclazide, vernonia anthelminiticum

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References


George P, Rudvid B. Lipids and Diabetes. J Clin Bio Card

;3:159-62.

Nyholm B, Porksen N, Juhl CB, Gravholt CH, Butler PC, Weeke J,

et al. Assessment of insulin secretion in relatives of patients with

Type2 (non-insulin-dependent) diabetes mellitus: Evidence of

early beta cell dysfunction. Metabolism 2000;49:896-905.

Eidi A, Eidi M, Smaeili EE, Antidiabetic eff ect of garlic (Allium

sativum. L) in normal and Streptomycin-induced diabetic rats.

Phytomedicine 2006;13:624-9.

Warrier PK. Indian medicinal plants. 1st ed. Vol. 5. Orient

Longman; 1994. p. 355.

Mehta RK, Parashar GC. The eff ect of Vernonia anthelminticum

and Cariea papaya against Oxyurids in mice. Indian J Vet

;8:744-8.

Parrott a JA. Healing plants of Peninsular India. New York: Cabi

Publication; 2001. p. 58-9.

Lazarow A. Alloxan diabetes and mechanism of beta-cell damage

by chemical agents. In: Hazarow A, editor. Experimental diabetes.

Oxford: Blackwell ScientiÞ c Publication; 1964. p. 49-69.

Rerup CC, Drugs producing diabetes through damage of insulin

secreting cells. Pharm Rev 1970;22:485-520.

Colca JR, Kotagel M, Brooks CL, Lacy PE, Handt M, McDaniel ML.

Alloxan Inhibition of Ca 2+ and Calmodulin - dependent protein

kinase in pancreatic islets. J Biol Chem 1985;225:260-3.

Yallow RS, Black H, Villazan M, Berson SA. Comparison of Plasma

insulin levels following administration of tolbutamide and glucose.

Diabetes 1960;9:356-62.

Abdel-Hassan IA, Abdel-Barry JA, Tariq Mohammeda S. The

hypoglycemic and anti hyperglycemic eff ect of Citrullus colocynthis

fruit aqueous extract in normal and alloxan diabetes rabbits. J

Ethnopharm 2000;71:325-30.

Cherian S, Kumar RV, Augusti KT, Kidwai JR. Antidiabetic eff ect

of glycoside of Pelargonidin isolated from the bark of Ficus

bengalensis. Indian J Biochem Biophy 1992;27:380-2.

Iwu MM, Okunji CO, Ohiaeri GO, Akah P, Corley D, Tempesta

MS. Hypoglycemic activity of discoretine from tubers of Discorea

dumetorum in normal and alloxan diabetic rabbits. Plant Med

;56:264-7.

Nakashima M, Kimura I, Kimura M, Matsuura H. Isolation of

pseudoprototimosaponin A 3 from rhizomes of Anemarrhena

asphodeloiales and its hypoglycemic activity in streptozotocin

induced diabetic mice. J Nat Prod 1993;56:345-50.

Petit PR, Sauvaire UD, Hillaire-Buys DM, Leconte OM, Baissae YG,

Ponsin GR, et al. Steroid saponins from fenugreek seeds: Extraction,

puriÞ cation and Pharmacological investigation of feeding behavior

of plasma. Choles Stero 1995;60:674-80.

Perez RM, Cervantes H, Zavala MA, Sanchez J, Perez S, Perez C.

Isolation and hypoglycemic activity of 5,7,3 trihydroxy 3,6,4

- trimethoxyß avone from Brickellia veronicaefolia. Phytomedicine

;7:25-9.

Hii CST, Howell SL. Eff ects of ß avonoids on insulin secretion

and 15ca2+ handling in rat islets of langerhans. J Endocrinol

;107:1-8.

Chauhan NS, Dixit VK. Antihyperglycemic activity of the ethanolic

extract of Curculigo orchioides Gaertn. Pharmoco Mag 2007;3:

-40.




DOI: http://dx.doi.org/10.22377/ijgp.v2i4.5

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