Investigation of analgesic activity of leaves part of the trianthema portulacastrum (L) in standard experimental animal models.

Shanmugam Suresh kumar, Sundaram Bama, Natarajan Kiruthiga, Ramanathan Sampath kumar, Thangavel Sivakumar, Palanisamy Dhanabal

Abstract


The ethanol extract of Trianthema portulacastrum belonging to the family of Aizoaceae was evaluated by acetic acid induced writhing
and hot plate methods to assess analgesic activity. It was found that the extract caused an inhibition on the writhing response induced by acetic acid in a dose dependent manner. Dose of 250 mg/kg EETP and Aspirin could block the writhing response by 50.92% and 67.68% (p<0.001), respectively. It was also indicated that the EETP showed significant antinociceptive action in hot plate reaction time method in mice. This effect was comparable to that of standard drug Aspirin treated controls, suggesting the central activity of EETP.
Key words: Trianthema portulacastrum, Analgesic activity, Acetic acid induced writhing and hot plate method.

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References


l Bisgaard H., Role of leukotrienes in asthma

pathophysiology, Ped Pulmo, 30, 2000, 166-76.

l Bley K. R., Hunter J. C., Eglen R. M., Smith J. A., The role of

IP prostanoid receptors in inflammatory pain, Trends

Pharmacol Science, 19, 1998, 141-147.

l Chopra R. N., Nayar S. L., Chopra I. C., Glossary of Indian

Medicinal Plants, CSIR, New Delhi, 1956, 246.

l Fields H. L., Analgesic drugs, In: Day W. (ed.) Pain, edn. 1,

MacGraw-Hill, USA, 1987, 272.

l Javed Ahmed, Farooqui A. H., Sageer Ahmed, J. Herbs

Species Med Plants, 7, 2000, 65.

l Kumar G., Sharmila Banu G., Vanitha Pappa P.,

Sundarrajan M., Rajasekar Pandian M., Journal of

Ethnopharmacol, 92, 2004, 37.

l Lavine J., Taiwo Y., Inflammatory pain. In: Wall, PD and

Melzack R. (eds.) Text book of pain. Churchill Living

Stone, New York, 1994, 45-56.

l Litchfield J. T., Wilcoxon F., A simplified method of

evaluating dose-effect experiments, Journal of

Pharmacol Exp Ther., 96, 1949, 99-135.

l Nadkarni K. M., Indian Materia Medica Vol. 1, Popular

Prakashan Private Ltd, Bombay, 1976, 1229.

l Plummer J. L., Cmielewski P. L., Gourlay G. K., Owen H.,

Cousins M., Assessment of antinoceptive drug effects in

the presence of impaired motor performance, Journal of

Pharmacol Meth, 26, 1991, 79-82.

l Raj P. P., Pain mechanism. In: Raj P. P., (ed.), Pain

medicine, A Comprehensive Review, Edn. 1, Mosby-Year

Book, Missouri, 1996, 12-23.

l Singh G. K., Dixit V. K., Indian Journal of Natural Products,

, 1991, 3.

l Turner R. A., Analgesic In: Turner R. A. and Hebborn P.

(eds.) Screening Methods In Pharmacology, P. Academic

Press, New York, 1960, 100-102.

l Wagner H., Bladt S., Zgainski E. M., Plant drug analysis,

Berlin, Heidelberg, New York, Tokyo: Springer-Verlag,

, 298-34.

l Vaidya B. L., Some Controversial Drugs in Indian

Medicine, Chaukhambha Orientalia, Varanasi, edn. 1,

, 201.

l Woolfe G., Mac Donalod A. D., The evaluation of analgesic

action of pethdine hydrochloride, Journal of Pharmacol

Exp Therapeut., 80, 1944, 300-04.




DOI: http://dx.doi.org/10.22377/ijgp.v1i1.411

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