Hepatoprotective activity of Trianthema decandra on carbon tetrachloride-induced hepatotoxicity in rats

Singaravel Sengottuvelu, Duraisamy Srinivasan, Rasilingam Duraisami, Jothivel Nandhakumar, Mani Vasudevan, Thangavel Sivakumar


Th e present study appraised the hepatoprotective activity of aqueous extract of Trianthema decandra roots against carbon tetrachlorideinduced liver damage. Liver damage was induced by intraperitoneal administration of an equal mixture of carbon tetrachloride and olive oil (50% v/v, 0.5 ml/kg) in male Wistar rats (150-220 g) once daily for 7 days and the extent of damage was studied by assessing the biochemical parameters such as alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP),
total protein and albumin in serum. Th e aqueous extract of Trianthema decandra roots (50 mg, 100 mg and 200 mg/kg) were orally administered to the animals with hepatotoxicity induced by carbon tetrachloride and its eff ects on biochemical parameters were compared with Silymarin (25 mg/kg) treated animals. Trianthema decandra (100 and 200 mg/kg) results in a signifi cant reduction in serum hepatic enzymes when compared to rats treated with carbon tetrachloride alone. Th ere was a signifi cant increase in the serum total protein and albumin when compared to rats treated with carbon tetrachloride alone. Th e results concludes that the aqueous extract of Trianthema decandra roots (100 and 200 mg/kg) has protected the liver from carbon tetrachloride-induced damage.
Key words: Carbon tetrachloride, hepatoprotective and silymarin, Trianthema decandra

Full Text:



Warrier PK, Nambiar VP, Ramankutt y C. Indian medicinal plants

a compendium of 500 species. vol. 1. India: Orient Longman Pvt

Ltd; 1994. p. 349-51.

Nadkarni KM. Indian materia medica. vol. 1. 3rd ed. Mumbai:

Popular Prakashan Pvt Ltd; 1996. p. 1228.

Javed A, Farooqui AH, Sageer A. Trianthema portulacastrum L an

herbal drug for the cure of edema. J Herbs Species Med Plants


Kumar G, Sharmila BG, Vanitha PP, Sundrarajan M,

Rajasekarapandian M. Hepatoprotective activity of Trianthema

portulacastrum L against paracetamol and thioacetamide

intoxication in albino rats. J Ethanopharmacol 2004;92:37-40.

Kumar G, Sharmila Banu G, Rajasekarapandian M. Evaluation of

the antioxidant activity of Trianthema portulacastrum L. Indian J

Pharmacol 2005;37:331-3.

Ecobichon DJ. The basis of toxicology testing. New York: CRC

Press; 1997. p. 43-86.

Rao PG, Rao SG, Kumar V. Effect of hepatoguard against

carbon tetrachloride induced liver damage in rats. Fitoterapia


Gupta M, Mazumder UK, Sambath Kumar R. Hepatoprotective

and antioxidant role of Caesalpinia bonducella on paracetamol

induced liver damage in rats. Nat Prod Sci 2003;9:186-91.

Gowenlock AH, McMurray JR, McLauchlan DM. Plasma proteins.

In: Varleys Practical Clinical Biochemistry. 6th ed. New Delhi: CBS

Publishers; 1988. p. 401-35.

Johnson DE, Kroening C. Mechanism of early Carbon tetrachloride

toxicity in cultured rat hepatocytes. Pharmacol Toxicol


Lim HK, Kim HS, Choi HS, Oh S, Choi J. Hepatoprotective eff ects

of bergenin, major constituent of Mallotus japonicus on CCl4

intoxicated rats. J Ethanopharmacol 2000;72:469-74.

Hayes JR, Londie LW, Leeca BJ. Acute 14 days repeated dosage and

dayssubchronic toxicity studies of CCl4 in CDI mice. Fundam

Appl Toxicol 1986;7:454.

Subramoniam A, Pushpangadan P. Development of phytomedicines

for liver diseases. Indian J Pharmacol 1999;31:166-75.

Burtes CA, Ashwood ER. Text book of clinical chemistry.

Philadelphia: WB Sunders Co; 1986. p. 56.

Mandal PK, Bishayee A, Chatterjee M. Studies of hepatic

protein synthesis in response to Mikania cordate root extract

in CCl4 induced hepatotoxicity in mice. Ital J Biochem


Sengottuvelu, et al.: Hepatoprotective activity of Trianthema decandra on carbon tetrachloride-induced hepatotoxicity in rats

DOI: https://doi.org/10.22377/ijgp.v2i2.45


  • There are currently no refbacks.