Hepatoprotective activity of Trianthema decandra on carbon tetrachloride-induced hepatotoxicity in rats

Singaravel Sengottuvelu, Duraisamy Srinivasan, Rasilingam Duraisami, Jothivel Nandhakumar, Mani Vasudevan, Thangavel Sivakumar

Abstract


Th e present study appraised the hepatoprotective activity of aqueous extract of Trianthema decandra roots against carbon tetrachlorideinduced liver damage. Liver damage was induced by intraperitoneal administration of an equal mixture of carbon tetrachloride and olive oil (50% v/v, 0.5 ml/kg) in male Wistar rats (150-220 g) once daily for 7 days and the extent of damage was studied by assessing the biochemical parameters such as alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP),
total protein and albumin in serum. Th e aqueous extract of Trianthema decandra roots (50 mg, 100 mg and 200 mg/kg) were orally administered to the animals with hepatotoxicity induced by carbon tetrachloride and its eff ects on biochemical parameters were compared with Silymarin (25 mg/kg) treated animals. Trianthema decandra (100 and 200 mg/kg) results in a signifi cant reduction in serum hepatic enzymes when compared to rats treated with carbon tetrachloride alone. Th ere was a signifi cant increase in the serum total protein and albumin when compared to rats treated with carbon tetrachloride alone. Th e results concludes that the aqueous extract of Trianthema decandra roots (100 and 200 mg/kg) has protected the liver from carbon tetrachloride-induced damage.
Key words: Carbon tetrachloride, hepatoprotective and silymarin, Trianthema decandra

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Sengottuvelu, et al.: Hepatoprotective activity of Trianthema decandra on carbon tetrachloride-induced hepatotoxicity in rats




DOI: http://dx.doi.org/10.22377/ijgp.v2i2.45

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