Antidiabetic activity of Annona squamosa Linn. in alloxan ‑ induced diabetic rats

Ranveer Singh Tomar, Siddharaj Singh Sisodia

Abstract


Background: Diabetes mellitus is characterised by rise in blood sugar levels resulting from insulin dysfunction or insulin insufficiency.
Aim: The aim of the present investigation is to evaluate antidiabetic activity of hydroalcoholic extract of Annona squamosa Linn (A. squamosa Linn) in alloxan‑induced diabetic rat model. Materials and Methods: Diabetes is induced by a single‑dose intraperitoneal injection (i.p.) of alloxan (120 mg/kg) to albino rats. Results and Discussion: Treatment with A. squamosa Linn. extract at a dose of 350 mg/kg and 700 mg/kg and glibenclamide at a dose of 5mg/kg for 28 days, after induction of diabetes by alloxan, caused significant
reduction in blood serum glucose and serum lipid profiles like total cholesterol and triglycerides but significant increase in body weight and serum high density lipoproteins (HDL) level in diabetic rats compared to untreated group. Histological study of the pancreas of diabetic rat treated with A. squamosa extract also showed partial regeneration of beta cells. The antidiabetic activity of this extract is found comparable to glibenclamide. Thus, leaves of A. squamosa Linn. can be used as potential antidiabetic drug.
Key words: Annona squamosa, antidiabetic, glibenclamide

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References


Tenpe CR, Yeole PG. Comparative evaluation of antidiabetic

activity of some marketed polyherbal formulation in alloxan

induced diabetic rats. J Pharma Tech Res 2009;1:43‑9.

Modak M, Dixit P, Londhe J, Ghaskadbi S, Devasagayam TP.

Indian herbs and herbal drugs for the treatment of diabetes. J Clin

Biochem Nutr 2007;40:163‑73.

Porwal M, Sharma K and Malik P. Anticovulsant Effect of Annona

squamosa Linn. Leaves in Mice. Pharmacologyoline 2011; 2:44‑52.

Shah R. Pharmacognosy and Pharmacology of Annona squamosa:

A review. Int J Pharm Life Sci 2011;2:1183‑9.

Pandey N, Barve D. Phytochemical and Pharmacological

Review on Annona squamosa Linn. Int J Res Pharm Biomed Sci

;2:1404‑8.

Lukacinova A, Mojzis J, Benacka R, Keller J, Kurila P, Vasko L,

et al. Preventive effects of flavonoids on alloxan induced diabetes

mellitus rats. Acta Vet Brno 2008;77:175‑82.

Vanitha V, Umadevi KJ, Vijaylakshmi K. Determination of bioactive

components of Annona squamosa L. Leaf by GC‑MS Analysis. Int

J Pharm Sci Drug Res 2011;3:309‑12.

Sivaiah K, Reddy GA. Evaluation of anti‑hyperlipidemic activity

of hydro alcoholic extract of moringa oleifera seeds in high fat diet

induced rat model. Int J Pharma Screen Meth 2012;2:72‑6.

Rathnakar UP, Hashim SD, Pemminatti S, Shenoy A,

Gopalkrishna HN, Siddique F, et al. Hypoglycaemic activity of

a polyherbal product in alloxan induced diabetic rats. Drug Int

Today 2011;3:1‑2.

Hugo WB, Russel AD. Pharmaceutical microbiology. 3rd ed.

Blackwell Science Publication; 1984. p. 179‑200.

Puranik N, Kararashah FK, Sheela D. Anti‑diabetic activity of

Tinospora cordifolia (Wild.) in Streptozotocin diabetic rats; does it

act like Sulfonylureas. Tur J Med Sci 2010;40:265‑70.

Srividya AR, Dhanabal SP, Satish Kr MN, Kumar P, Baradia H.

Antidiabetic and antioxidant activity of Alpinia galanga. Int J Pharm

Phytochem Res 2010;3:6‑12.

Obaidullah L, Ikramullah KL, Zafar I, Wilayat A, Shah NM. Study

of hypolipidemic effect of herbal and homeopathic antidiabetic

drugs in alloxan induced diabetic rabbits. Int J Pharma Med Chem

;2:183‑7.




DOI: http://dx.doi.org/10.22377/ijgp.v8i4.419

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