Anti-hyperglycemic and antioxidant activities of the ayurvedic drug - premahaoushadhi choornam in alloxan induced diabetic rats.

Ch. Jithendra, P. Muralidharan, S. Venkataraman


Diabetes, the most prevailing metabolic disorder, is attracting present research attention towards it. In the present study, we have designed to evaluate the antihyperglycemic and antioxidant potential of Premahaoushadhi choornam (POC), a poly herbal ayurvedic formulation, widely used in southern parts of India in the treatment of diabetes. The effect of POC on normoglycemic rats and on hyperglycemia induced with alloxan (120 mg/kg) on single and repeated administration of POC was evaluated. The antioxidant potential of the extract was estimated in the heart and pancreas after repeated administration of POC in alloxan induced diabetic rats. The results were satisfactory, as a significant decrease in the blood glucose levels after repeated administration was observed. The reversal of the decreased antioxidant enzyme levels in the heart and pancreatic tissues of diabetic rats suggest its efficacy against diabetes and
oxidative damage.
Key words: Premahaoushadhi choornam, Diabetes, Alloxan, Glibenclamide, antioxidants.

Full Text:



| Anna G., Hanna H., Zbigniew W. and Justyna N., Acta

biochemica polonica, 2002, 2, 529.

l Nagarajan N. S., Murgesh N., Thirupathy Kumaresan P.,

Radha N. and Murali A., Fitoterpia, 2005, 76, 310.

l Venkatesh S., Dayanand Reddy G., Madhava Reddy B.,

Ramesh M. and Apparao A. V. N., Fitoterpia, 2003, 74,

l Satyanarayana S., Satyavati D. and Venkata Rao D.,

Ind. J. Exp. Biol., 2000, 38, 180.

l Sharma S. R., Dwivedi S. K. and Swarup D., Ind. J.

Exp. Biol., 1996, 34, 372.

l Manomani G., Bhavapriya V., Kalpana S., Govindaswamy

S. and Apparanantham T., J. eth. Pharmacol., 2005, 97,

l Kamalakannan N. and Prince, A. M., Ind. J. Exp. Biol.,

, 41, 1285.

l Misra D. P. and Fridovich I., J. Biol. Chem., 1972, 247,

l Gerald C., Borothy D. and Judith M., Anal. Bio. Chem.,

, 34, 30.

l Necheles T. F., Boles T. A. and Allen D. M., J. Bio. Chem.,

, 5, 239.

l Charles E. and Robert G., J. Bio. Chem., 1981, 5, 234.

l Devasgayam T. P. A., Baloor K. K. and Ramasarma T., I. J.

Bio. Chem. & Biophysics, 2003, 40, 300.

l Szkudelski T., Physiol. Res., 1999, 50, 536.

l Halliwell B., Aeschbach R., Loligger J. and Aruoma O. L.,

Federal Chemical Toxicology, 1995, 33, 601.

l Jakus V., Bratisl Lek Listy, 2000, 10, 541.



  • There are currently no refbacks.