Anti-oxidant activity of ethyl acetate extract of Aquilaria agallocha on nitrite-induced methemoglobin formation

P. B. Miniyar, T. S. Chitre, S. S. Karve, H. J. Deuskar, K. S. Jain

Abstract


Aquilaria agallocha Roxb, family Th ymelaeaceae, is an evergreen plant of India, China and Tibet, commonly described as aloe wood or agar wood. Traditionally, bark, root and heartwood are used for their medicinal properties as a folk medicine to treat infl ammation, arthritis, vomiting, cardiac disorders, cough, asthma, leprosy, anorexia, headache and gout. Th e present study was carried out to investigate
the antioxidant activity of ethyl acetate extract of Aquilaria agallocha (EAA). EAA was tested in vitro at diff erent concentrations for inhibitory eff ect on nitrite-induced oxidation of haemoglobin in human blood hemolysate. Results indicate a strong antioxidant eff ect of EAA in a concentration range of 500-3500 μg/ml. However, pro-oxidant activity was observed at higher concentrations of these compounds.
Key words: Aquilaria agallocha, antioxidant, nitrite-radical, methemoglobin

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References


Bhandari P, Pant P, Rastogi RP, Aquillochin: A coumarinolignan

from Aquilaria agallocha, Phytochemistry, 21, 1982, 2147-2149.

Doyle MP, Pickering RA, Dykstra RL, Nelson CL, Boyer RF,

Biochem. Biophysics. Res. Commun, 105, 1982, 127.

Ishihara M, Tsuneya T, Shiga M, Uneyama K, Sequiterpenes from

agar wood, Phytochemistry, 30, 1991, 563-566.

Iyer SR, Indian Medicinal Plants - a compendium of 500 species.

Orient Longman, Hyderabad, India, 1994.

Kim YC, Lee EH, Lee YM, Kim HK, Song BK, Lee EJ, Kim HM, Eff ect

of aqueous extract of Aquilaria agallocha stems on the immediate

hypersensitive reactions, J. Ethanpharmcol, 58, 1997, 31-38.

Kirtikar KR, Basu BD, Plate volume IV. In: Indian Medicinal Plants.

International Book Distributors, Dehradun, India, 1999, 836.

Manjunath BL, The Wealth of India - A dictionary of Indian

raw materials and Industrial Products, CSIR, New Delhi, India,

Miles AM, Grisham MB, Methods in Enzymology, 234, 1994, 555.

Nadkarni KM, Nadkarni KA, Indian Materia Medica, Popular

Prakashan Private Limited, Mumbai, India, 1976.

Unnikrishnan MK, Rao MNA, Inhibition of nitrite induced

oxidation of hemoglobin by curcuminoids, Pharmazie, 50, 1995,

Unnikrishnan MK, Rao MNA, Curcumin inhibits nitrogen

dioxide induced oxidation of hemoglobin, Mol. Cell. Biochem,

, 1995, 35.




DOI: http://dx.doi.org/10.22377/ijgp.v2i1.395

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