Sperm function and fertility profile following nicotine administration in male rats: Protective potentials of Zingiber officinale

Ibukun P. Oyeyipo, Olawale O. Obembe, Olayemi O. Oladokun, Yinusa Raji

Abstract


Background: It is well documented that Zingiber officinale has androgenic property while nicotine induce infertility through hormonal imbalances, but there are no data in the open scientific literature that have examined the effects of Z. officinale in preventing nicotine‑induced infertility. This study was carried out to investigate the effect of Z. officinale on nicotine‑induced reproductive toxicity in male rats. Materials and Methods: Thirty‑two male albino rats were randomly divided into four groups (n = 8). Group 1 served as the control, group 2 was administered with 1.0 mg/kg body weight (BW) of nicotine orally for 30 days, group 3 was administered with 1.0 mg/kg BW
of nicotine alongside with 500 mg/kg BW/day of aqueous extract of Z. officinale and group 4 was administered with 500 mg/kg BW/day of aqueous extract of Z. officinale. Semen analysis showing sperm count, morphology, motility, volume and viability was carried out. Fertility study, litter weight and size were also determined. Testosterone was also assayed. Results: Nicotine treatment significantly decreased sperm count, motility, normal morphology and serum testosterone level. There was a decrease in libido, litter weight and number delivered by the untreated cohabited female during the experiments. However, the extract prevented the decrease in sperm quality and hormonal
imbalances caused by nicotine. Conclusion: This finding shows that aqueous extract of Z. officinale prevented nicotine‑induced infertility during nicotine administration and possesses pro‑fertility potentials attributed to the androgenic properties of the plant.
Key words: Hormone, nicotine, sperm, Zingiber officinale

Full Text:

PDF

References


Ernst E, Pittler MH. Efficacy of ginger for nausea and vomiting:

A systematic review of randomised clinical trials. Br J Anaesth

;84:367‑71.

Morakinyo A, Adeniyi O, Arikawe A. Effects of Zingiber Officinale

on male reproductive functions in the male rat. Afr J Bio Res

;11:327‑34.

Kamtchouing P, Mbongue Fandio GY, Dimo T, Jastra HB.

Evaluation of androgenic activities of Zingiber Officinale and

Pentadiplandra brazzeano in male rats. Asian J Androl 2002;4:299‑301.

Ahmed MA, Sajida HI. Protective effect of ginger extract against

Cisplatin‑indiced Hepatotoxicity and cardiotoxicity in rats. Iraq J

Pharm Sci 2012;21:27‑33.

Di Chiara G. Role of dopamine in the behavioural actions of

nicotine related to addiction. Eur J Pharmacol 2000;393:295‑314.

Harvey DM, Yasar S, Heishman SJ, Panlilio LV, Henningfield JE,

Goldberg SR. Nicotine serves as an effective reinforcer of

intravenous drug taking behavior in human cigarette smoking.

Psychopharmocology (Berl) 2004;175:134‑42.

Russell MA, Jarvis MJ, Devitt G, Feyerabend C. Nicotine intake

by snuff users. Br Med J (Clin Res Ed) 1981;283:814‑7.

Armitage AK, Dollery CT, George CF, Houseman TH, Lewis PJ,

Turner DM. Absorption and metabolism of nicotine from

cigarettes. Br Med J 1975;4:313‑6.

Oyeyipo IP, Raji Y, Emikpe BO, Bolarinwa AF. Effects of oral

administration of nicotine on organ weight, serum testosterone

level and testicular histology in adult male rats. Niger J Physiol

Sci 2010;25:81‑6.

Oyeyipo IP, Raji Y, Emikpe BO, Bolarinwa AF. Effects of nicotine

on sperm characteristics and fertility profile in adult male rats:

A possible role of cessation. J Reprod Infertil 2011;12:201‑7.

Raji Y, Udoh US, Mewoyeka OO, Ononye FC, Bolarinwa AF.

Implication of reproductive endocrine malfunction in male

antifertility efficacy of Azadirachta indica extract in rats. Afr J Med

Med Sci 2003;32:159‑65.

Morrissey RE, Schwetz BA, Lamb JC 4th, Ross MD, Teague JL,

Morris RW. Evaluation of rodent sperm, vaginal cytology, and

reproductive organ weight data from 4th National Toxicology

Program 13‑week studies. Fundam Appl Toxicol 1988;11:

‑58.

Wyrobek AJ, Bruce WR. The induction of sperm shape

abnormalities in mice and humans. In: Hollaender A, De Serres FJ,

editors. Chemical Mutagens, Vol. 5. New York: Plenum Press; 1980.

p. 257‑85.

Freund M, Carol B. Factors affecting haemocytometer count

of sperm concentration in human semen. J Reprod Fertil

;8:149‑55.

Dhawan K, Sharma A. Prevention of chronic alcohol and

nicotine‑induced azospermia, sterility and decreased libido,

by a novel tri‑substituted benzoflavone moiety from Passiflora

incarnata Linneaus in healthy male rats. Life Sci 2002;71:3059‑69.

Bolarinwa Y. Gastric acid secretion in pregnant and lactating rat.

Trop Vet 1993;11:35‑8.

Raji Y, Oloyo AK, Morakinyo AO. Effect of methanol extract of

Ricinus communis seed on reproduction of male rats. Asian J

Androl 2006;8:115‑21.

Aydos K, Güven MC, Can B, Ergün A. Nicotine toxicity to the

ultrastructure of the testis in rats. BJU Int 2001;88:622‑6.

Sharpe RM, Maddocks S, Millar M, Kerr JB, Saunders PT,

McKinnell C. Testosterone and spermatogenesis. Identification

of stage‑specific, androgenregulated proteins secreted by adult

rat seminiferous tubules. J Androl 1992;13:172‑84.

Yamamoto Y, Isoyama E, Sofikitis N, Miyagawa I. Effects of

smoking on testicular function and fertilizing potential in rats.

Urol Res 1998;26:45‑8.




DOI: http://dx.doi.org/10.22377/ijgp.v8i2.373

Refbacks

  • There are currently no refbacks.