Genus Prismatomeris (Rubiaceae): Phytochemistry and their biological activities

Abstract

Prismatomeris is a genus of the family Rubiaceae, which is mainly distributed in Southeast Asia. Some of the species were used to treat wounds, hepatitis, anemia, leukocythemia, pneumoconiosis, bronchitis, and as aphrodisiac. Up to now, the reported constituents from the genus Prismatomeris include anthraquinones, iridoids, and triterpenoids. Among them, anthraquinones, the characteristic components of this species become an intention due to their complex structures and significant biological features such as cytotoxic, antitumor, anticancer, antifungal, antimalarial, antiplasmodial, and antituberculosis activities. This review presents a systematic compilation of available data of secondary metabolites and their bioactivity studies of the genus Prismatomeris. It may lead to upcoming drug design, and therefore, provide a reference for advanced study and application of Prismatomeris.