Antitumour activity of ethanolic extract of leaves of Holoptelea integrifolia on Dalton’s ascitic lymphoma in Swiss albino mice

Lakshmi K. S, Shrinivas S. Sharma, Rajesh T., Chitra V.

Abstract


The antitumour activity of the ethanolic extract of leaves of Holoptelea integrifolia (EHI) has been evaluated against Dalton’s ascitic lymphoma (DAL) in Swiss albino mice at the dose of 250 and 500 mg/kg, body weight. The experimental parameters were evaluated like tumour volume, tumour cell count, viable tumour cell count, mean survival time and increase in life span to assess antitumour activity. The extract was administered orally for 14 consecutive days to tumour bearing group of animals. The extract increased the life span of DAL treated mice and restored the hematological parameters as compared with the DAL bearing mice in a dose-dependant manner. The study revealed that the EHI showed significant antitumour activity in tested animal models.
Key words: Holoptelea integrifolia, Dalton’s ascitic lymphoma, lifespan, tumour volume

Full Text:

PDF

References


Ramakrishna Y, Manohor AI, Mamata P, Shreekant KG. Plants and

novel antitumour agents: A review. Indian Drugs 1984;21:173-85.

Anonymous, Wealth of India, Raw Materials. Vol. V, 2001. New

Delhi: Publication and Information Directorate (CSIR); India.

p. 109.

Rajbhandari M, Wegner U, Jülich M, Schöpke T, Mentel R.

Screening of Nepalese medicinal plants for antiviral activity. J

Ethnopharmacol 2001;74:251-5.

Srinivas Reddy B, Kiran Kumar Reddy R, Naidu VG,

Madhusudhana K, Agwane SB, Ramakrishna S, et al. Evaluation

of antimicrobial, antioxidant and wound-healing potentials of

Holoptelea integrifolia. J Ethnopharmacol 2008;115:249-56.

Bambhole VB, Jiddewar GG. Anti-obesity effect of Iris versicolor

and Holoptelea integrifolia in rats. Sachitra Ayurved 1985;37:557-61.

Graham JG, Quinn ML, Fabricant DS, Farnsworth NR. Plants used

against cancer-an extension of the work of Jonathan Hartwell. J

Ethnopharmacol 2000;73:347-77.

Gothoskar SV, Ranadive KJ. Anticancer screening of SAN-AB; an

extract of marking nut, Semicarpus anacardium. Indian J Exp Biol

;9:372-5.

Sharma S, Lakshmi KS, Patidar A, Chaudhary A, Dhaker S.

Studies on anti-inflammatory effect of aqueous extract of leaves

of Holoptelea integrifolia, Planch. in rats. Indian J Pharmacol

;41:87-8.

Mazumdar UK, Gupta M, Maiti S, Mukherjee D. Antitumour

activity of Gygrophila spinosa on Ehrlich ascites carcinoma and

sarcoma-180 induced mice. Indian J Exp Biol 1997;35:473-7.

Sur P, Ganguly DK. Tea plant root extract (TRE) as an antineoplastic

agent. Planta Med 1994;60:106-9.

Dacie JV, Lewis SM. Practical Hematology. 2nd ed. J and A Churchill,

London. 1958. p. 38-48.

D’Armour FE, Blood FR, Belden DA. The Manual for Laboratory

Work in Mammalian Physiology. 3rd ed. The University of Chicago

Press, Illinois. 1965. p. 4-6.

Clarkson BD, Burchenal JH. Preliminary screening of antineoplastic

drugs. Progress Clin Cancer 1965;1:625-9.

Obiling C, Guerin M. The Role of Viruses in the Production of

Cancer. Adv Cancer Res II . Academic Press: New York; 1954. p.

-11.

Price VE, Greenfield RE. Anemia in cancer. In: Grenstein, J.P.,

Haddow, A. (Eds.), Advance in Cancer Research, vol. 5. Academic

Press: New York; p. 199-200.

Hogland HC. Hematological complications of cancer chemotherapy.

Sem Oncol 1982;9:95-102.

Brown JP. A review of the genetic effect of naturally occurring

flavonoids, anthraquinones and related compounds. Mutat Res

;75;243-7.

Hirano T, Oka K, Akiba M. Antiproliferative effect of synthetic and

naturally occurring flavonoids on tumour cells of human breast

carcinoma cell lines, ZR-75-1. Res Commun Pathol Pharmacol

;64:69-78.

Weber G, Shen F, Prajda N, Yeh YA, Yang H, Herenyiova M,

et al. Increased signal transduction activity and down regulation

in human cancer cells. Anticancer Res. 1996;16:3271-82.

Fotsis T, Pepper MS, Aktas E, Breit S, Rasku S, Adlercreutz H,

et al. Flavonoids, dietary-derived inhibitors of cell proliferation

and in vitro angiogenesis. Cancer Res 1997;57:2916-21.




DOI: http://dx.doi.org/10.22377/ijgp.v4i1.118

Refbacks

  • There are currently no refbacks.