Antidiabetic activity of a polyherbal formulation (Karnim Plus)

Abstract

Karnim Plus, an herbal formulation marketed for diabetes, was investigated for its glucose tolerance, hypoglycaemic, and antidiabetic effects in rats. The glucose tolerance test was studied at 400 mg/kg. Hypoglycemic studies were carried out in normal rats at two dose levels, 200 mg/kg and 400 mg/kg. Antidiabetic effect was analyzed in alloxan-induced diabetic rats at two dose levels, 200 mg/kg and 400 mg/kg. Glibenclamide, 4 mg/kg, was used as the standard drug. The biochemical parameters such as glucose, urea, creatinine, serum cholesterol, and serum triglyceride were also assessed in experimental animals. The product showed its effectiveness in oral
glucose tolerance test and antidiabetic activity, but it did not produce hypoglycemic effect. Treatment of diabetic rats with the product restored the elevated biochemical parameters significantly. The present study supports the use of this product as an antidiabetic.
Key words: Karnim Plus, antidiabetic activity, Momordica charantia, Azadirachta indica, Picrorrhiza kurroa, Ocimum sanctum,
Zingiber officinale