Evaluation of antinociceptive effect of Xanthium strumarium Linn. leaves extract in Swiss albino mice

Atul S. Akarte; Vishwas C. Bhagat; Pradeep T. Deshmukh; Chandrakant Disle

doi:10.22377/ijgp.v3i2.73

Evaluation of antinociceptive effect of Xanthium strumarium Linn. leaves extract in Swiss albino mice

Atul S. Akarte, Vishwas C. Bhagat, Pradeep T. Deshmukh, Chandrakant Disle

Abstract

The aim of this study was to explore the probable antinociceptive effect of an ethanolic extract of Xanthium strumarium L. leaves in Swiss albino mice by using models of Eddyâ€™s hot plate test, tail immersion test and acetic acid induce writhing test. Swiss albino mice were treated i.p. with saline water (control), test group treated with 50, 100, 200 and 400 mg/kg extract per oral, standard group treated with pentazocin 3 mg/kg. The results are expressed as the mean Â± SEM. and statistically analyzed using one-way analysis of variance (ANOVA) followed by a Student-Newman-keuls test for multiple comparisons using Graph Pad Instant statistical program. Values of p< 0.05 were considered to be significant. The ethanolic extract showed the dose-dependent antinociceptive activity in Eddyâ€™s hot plate test, tail immersion test and acetic acid induce writhing test at time intervals 15, 30, 60 and 120 min.
Key words: Antinociceptive activity, ethanolic extract, Xanthium strumarium Linn

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References

Pharmacopoeia PR China I (English Edition). Beijing: Chemical

Industry Press; 2000. p. 91-2.

Zhu YP. Chinese materia medica: Chemistry, pharmacology and

applications. Amsterdam: Harwood Academic Publishers; 1998.

p. 73-6.

Nadkarni AK. Indian Materia Medica, Vol. 1. Mumbai: Popular

Prakashan; 1954. p. 1298.

Chopra RN, Chopra IC, Handa KL, Kapur LD. Indigenous Drugs

of India, 2nd ed. Calcutta: UN Dhar and Sons; 1958. p. 438.

Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN, Ray C. Screening

of Indian plants for biological activity: Part I. Indian J Exp Biol

;6:232-47.

Jawad AL, Mahmould MJ, AI-Naib A. Antimicrobial activity of

Xanthium strumarium extracts. Fitoterapia 1988;59:220-1.

Hana T, Lib HL, Zhanga QY, Hana P, Zhenga HC, Rahmanc K,

et al. Bioactivity-guided fractionation for anti-inflammatory and

analgesic properties and constituents of Xanthium strumarium L.

Phytomedicine 2007;14:825-9.

Kulkarni SK. Hand book of experimental pharmacology. Delhi:

Vallabh Prakashan; 2001. p. 127- 8.

Fadeyi. Antipyretic, analgesic, antiinflamatory and cytotoxic effects

of four derivative of salicylic acid and anthranilic acid in mice and

rats. Afr J Biotechnol 2004;3:426-31.

Kulkarni SK. Hand book of experimental pharmacology. Delhi:

Vallabh Prakashan; 2001. p. 125-7.

Mishima S, Inoh Y, Narita Y, Ohta S, Sakamoto T, Araki Y, et al.

Identification of caffeoylquinic acid derivatives from Brazilian

propolis as constituents involved in induction of granulocytic

differentiation of HL-60 cells. Bioorg Med Chem 2005;13:5814-8.

Hamauzu Y, Yasui H, Inno T, Kume C, Omanyuda M. Phenolic

profile, antioxidant property, and antiinfluenza viral activity

of Chinese quince (Pseudocydonia sinensis Schneid.), quince

(Cydonia oblonga Mill.) and apple (Malus domestica Mill.) fruits.

J Agric Food Chem 2005;53:928-34.

Jiang RW, Lau KM, Hon PM, Mak TC, Woo KS, Fung KP. Chemistry

and biological activities of caffeic acid derivatives from Salvia

miltiorrhiza. Curr Med Chem 2005;12:237-46.

Zhang AL, Ma Q, Gao JM. Studies on bioactivities of chlorogenic

acid and its analogues. Zhong Cao Yao 2001;32:173-6.

Dos Santos MD, Gobbo-Neto, L, Albarella, L, de Souza GE,

Lopes NP. Analgesic activity of di-caffeoylquinic acids from roots

of Lychnophora ericoides (Arnica da serra). J Ethnopharmacol

;96:545-9.

DOI: https://doi.org/10.22377/ijgp.v3i2.73

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