Exploring neuroprotective potential of Cissus quadrangularis plant extract in Parkinson’s disease

Ranjan Chauhan


Background: Parkinson’s disease (PD) caused due to neuroinflammation and oxidative stress associated with
motor and non-motor complications. Neuroprotection strategies create a hope for patients. Natural products have
been increasing the gain to have specific molecular or pharmacological activities that are likely to supply the
development of neuroprotective agents against PD. Cissus quadrangularis constitutes all suitable physical and
chemical properties and its ability to cross the blood–brain barrier making it a relevant candidate for the treatment
of neuroprotection in PD. Materials and Methods: The stem part of the plant was extracted with distilled water
and ethanol. The antiparkinson’s activity of both extracts of C. quadrangularis was evaluated using rotenoneinduced
excitotoxicity model in zebrafish for 96 h resulting in alterations in swimming pattern measured through
a video recording system. Further, cognitive improvement activity in PD of both extracts of plant was evaluated
using reserpine-induced cognitive impairments in mice for 29 days. Biochemical parameters, that is, levels of
catalase and glutathione (GSH) were analyzed using UV-visible spectrophotometer. Results: The aqueous extract
of C. quadrangularis (AECQ) showed a significant and dose-dependent effect against rotenone-induced PD in
adult zebrafish’s at a dose of 4 and 10 ?g/mL and cognitive improvement activity against reserpine-induced
cognitive impairment in mice at a dose of 200 mg/kg and 500 mg/kg. The AECQ also showed a significant in vivo
antioxidant potential by restoring the levels of catalase and GSH. The results of the present study demonstrate
the potential antiparkinson’s properties of the aqueous extract. Conclusion: The result of the present study
conclusively shows the Anti-Parkinson’s activity of C. quadrangularis and improved cognition in PD.

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DOI: https://doi.org/10.22377/ijgp.v17i03.3476


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