In vitro anthelmintic activity of Acacia catechu Willd

Suyog H. Patil, Pooja V. Deshmukh, S. A. Sreenivas, K. Sangameshwar, Laxman S. Vijapur


Aim: The present study was designed to evaluate the anthelmintic activity of heartwood of Acacia catechu Willd.
Materials and Methods: The alcoholic extract of heartwood of Acacia catechu Willd and its ethyl acetate fractions at different
concentrations were tested on Indian adult earthworms (Pheretima posthuma) by in vitro standard procedure. Time of paralysis and time of death of the worms were considered as the parameters to assess the anthelmintic action. Albendazole and 2% w/v gum acacia in distilled water were used as standard and control respectively. Results: The ethyl acetate fraction of alcoholic extracts exhibited potent anthelmintic activity compared to alcoholic extract as evidenced by a significant decrease in time of paralysis and death. The observed activity could be due to the presence to phenolic compounds, particularly flavonoids in the test extract. Conclusion: These in vitro studies indicated that the A. catechu Willd. is a significant source of natural anthelmintic, which might be helpful in preventing the
progress of various parasitic disorders.
Key words: Acacia catechu, alcoholic extract, anthelmintic activity, death, ethyl acetate fraction, paralysis

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