Screening of Careya arborea Roxb for their anticonvulsant properties in experimental animals
Abstract
Aims: The aim of the present study was to evaluate anticonvulsant activity of C. arborea Linn. bark against experimental induced
seizures. Settings and Design: Convulsion was induced by maximal electroshock seizures (MES), pentylenetetrazol (PTZ)
and PTZ‑induced kindling model. Materials and Methods: Petroleum ether (PE), chloroform (CH), methanol (ME) and
aqueous (AQ) extract of C. arborea bark at 150 and 300 mg/kg b.w. were administered in all models. Statistical Analysis:
Mean values and standard error mean was determined for all models and data was analyzed by one‑way ANOVA, followed by
Dunnett’s test. Results and Conclusion: The ME and AQ extract of C. arborea bark at 300 mg/kg b.w. p.o. showed the most
significant (P < 0.01) anticonvulsant effect by decreasing the duration of hind limb extension (extensor phase), clonus and
also the duration of stupor phase, as compared with control in MES and PTZ and the extracts also inhibited seizure score in
PTZ‑induced kindling model.
Key words: Careya arborea Roxb, maximum electroshock, pentylenetetrazol, pentylenetetrazol kindling
Full Text:
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James O. McNamara, Drugs effective in the therapy of the
epilepsies. In: Goodman Gilman’s The Pharmacological Basis of
Therapeutics, Hardman JG, Limbrid LE, Gilman G, Goodman A,
editors. 10th ed. USA: The McGraw‑Hill Companies; 1996. p. 521‑48.
Senthilkumar N, Badami S, Cherian MM, Hariharapura RC. Potent
in vitro cytotoxic and antioxidant activity of Careya arborea bark
extracts. Phytother Res 2007;21:492‑5.
Natesan S, Badami S, Dongre SH, Godavarthi A. Antitumor activity
and antioxidant status of the methanol extract of Careya arborea
bark against Dalton’s lymphoma ascites‑induced ascitic and solid
tumor in mice. J Pharmacol Sci 2007;103:12‑23.
Mandal D, Panda N, Kumar S, Banerjee S, Mandal NB, Sahu NP.
A triterpenoid saponin possessing antileishmanial activity from
the leaves of Careya arborea. Phytochemistry 2006;67:183‑90.
Rahman MT, Khan OF, Saha S, Alimuzzaman M. Antidiarrhoeal
activity of the bark extract of Careya arborea Roxb. Fitoterapia
;74:116‑8.
Kirtikar KR, Basu BD.Phanerogamia: C areya Roxb. Indian
Medicinal Plants. 2nd ed. Dehradun, India: International Book
Distributors; 2006. p. 1061‑3.
Nadkarni AK. Vegetable Kingdom. The Indian Materia Medica.
rd ed. Mumbai, India: Popular Prakashan Pvt Ltd; 1998. p. 273.
Harborne JB. Methods of extraction and isolation, Phytochemical
methods. 3rd ed. London: Chapman and Hall; 2007. p. 4‑6.
Gupta YK, Sharma M, Chaudhary G. Antiepileptic activity of Panax
ginseng against pentylenetetrazol induced kindling in rats. Indian
J Physiol Pharmacol 2001;45:502‑6.
Pandhare RB, Mohite PB, Khanage SG, Sangameswaran B.
In vivo anticonvulsant activity of Aegle marmelos Corr. against
pentylenetetrazol and electroconvulsive seizure in mice. J Pharm
Res 2009;2:1852‑4.
Patil KS, Suresh Babu AR, Chaturvedi SC. Anticonvulsant
activity of roots and bark of Calotropis gigantea Linn. J Nat Rem
;8:109‑14.
Duraiswami R, Shreenivasan D. Anticonvulsant activity of
bioflavonoid gossypin. Bangladesh J Pharmacol 2009;4:51‑4.
Kulkarni SK. Experiment on Intact preparation: Pharmacology of
CNS. Handbook of Experimental Pharmacology. 3rd ed. Mumbai:
Vallabh Prakashan; 1999. p. 131‑4.
Sayyah M, Mandgary A, Kamalinejad M. Evaluation of the
anticonvulsant activity of the seed acetone extract of Ferula
gummosa Boiss. against seizures induced by pentylenetetrazol
and electroconvulsive shock in mice. J Ethnopharmacol
;82:105‑9.
Amabeoku G. Anticonvulsant activity of Nylandtia spinosa L.
Dumont (Polygalaceae) aqueous and methanol leaf extracts in
mice. Hum Exp Toxicol 2008;27:811‑8.
Kaur M, Goel RK. Anticonvulsant activity of Boerhaavia diff usae.
eCAM; 2011. p. 1-7.
Johnston GA, Hanrahan JR, Chebib M, Duke RK, Memelt KN.
Modulation of ionotropic GABA receptors by natural products
of plant origin. Australia: The University of Sydney; 2006.
p. 289‑96.
Du X, Sun NY, Takizawa N, Guo YT, Shoyama Y. Sedative and
anticonvulsant activities of goodyerin, a flavonol glycoside from
Goodyera schlechtendaliana. Phytother Res 2002;16:261‑3.
DOI: https://doi.org/10.22377/ijgp.v7i1.292
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