Screening of Careya arborea Roxb for their anticonvulsant properties in experimental animals

Gulab S. Shinde, Ravindra V. Karadi, Ajay S. Khedkar, Pravin J. Dere, Yuvaraj D. Mandavkar, Pallavi R. Khalure


Background: Bark of Careya arborea Roxb are traditionally used in the ayurvedic system of medicine for the treatment of epilepsy.
Aims: The aim of the present study was to evaluate anticonvulsant activity of C. arborea Linn. bark against experimental induced
seizures. Settings and Design: Convulsion was induced by maximal electroshock seizures (MES), pentylenetetrazol (PTZ)
and PTZ‑induced kindling model. Materials and Methods: Petroleum ether (PE), chloroform (CH), methanol (ME) and
aqueous (AQ) extract of C. arborea bark at 150 and 300 mg/kg b.w. were administered in all models. Statistical Analysis:
Mean values and standard error mean was determined for all models and data was analyzed by one‑way ANOVA, followed by
Dunnett’s test. Results and Conclusion: The ME and AQ extract of C. arborea bark at 300 mg/kg b.w. p.o. showed the most
significant (P < 0.01) anticonvulsant effect by decreasing the duration of hind limb extension (extensor phase), clonus and
also the duration of stupor phase, as compared with control in MES and PTZ and the extracts also inhibited seizure score in
PTZ‑induced kindling model.
Key words: Careya arborea Roxb, maximum electroshock, pentylenetetrazol, pentylenetetrazol kindling

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