Ameliorative potential of Vigna mungo seeds on hyperglycemia mediated oxidative stress and hyperlipidemia in STZ diabetic rats

Jangra Meenu, Sunil Sharma, Manoj Kumar


Ethnomedicinally the seeds of Vigna mungo are used as cooling astringent, diet during fever, poultice for abscesses, soap alternative. The increased oxidative stress plays an important role in the etiology and pathogenesis of diabetes mellitus and its various complications. This study was designed to examine the effect of hydroalcoholic extract (VME) of V. mungo seeds on STZ-diabetic rats by measuring glycemia, lipid profile, and lipid peroxidation parameters (MDA, PCO, and GSH) and antioxidant enzymes activities (SOD, CAT, and GPx). The levels of glucose, TG, TC, MDA, and PCO were increased significantly whereas the levels of serum insulin, reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and Glutathione peroxidise (GPx) were decreased in STZ induced diabetic rats. Administration of VME (200 mg/kg bw and 400 mg/kg bw p.o.) to diabetic rats for 28 days showed a significant decrease
in serum glucose, TG, TC, MDA, and PCO. In addition, we also summarize here that the levels of serum insulin, superoxide dismutase, catalase, GPx, and reduced glutathione (GSH) were increased in VME treated diabetic rats. The antioxidant and antihyperglycemic effect of VME was compared with glibenclamide, a well-known antioxidant and antihyperglycemic drug. The findings in this study suggest that the VME possesses a significant favourable effect on antioxidant defense system in addition to its antidiabetic effect. Nonetheless, this study provides evidence that could help explain how the traditional use of V. mungo has been successful in the treatment of various disorders in humans.
Key words: Antihyperglycemic, oxidative stress, Vigna mungo

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