Evaluation of anti-diarrhoeal potential of ethanolic extract of Mimosa pudica leaves

Md. Saifuddin Khalid, Shah Jinesh Kumar, D. K. Suresh, Rajnish Kumar Singh, I. V. Narasimha Reddy, Sunil Kumar

Abstract


Diarrhoea is a major public health problem in developing countries and is said to be endemic in many regions of Asia. It is a leading cause of high degree of morbidity and mortality. The anti-diarrhoeal potential of the ethanolic extract of leaves of Mimosa pudica Linn (Mimosaceae) has been evaluated using several experimental models in Wistar albino rats. The ethanolic extract inhibited castor oil induced diarrhoea and PGE2 induced enteropooling in rats and has also reduced gastrointestinal motility after charcoal meal administration. The ethanolic extract at 200 and 400 mg/kg was showed significantly inhibited diarrhoea. There was a significant (P<0.001) dose-dependent decrease in the diarrhoea produced by all the three models in rats as compared to the standard drug. The anti-diarrhoeal property may be related to the tannin and flavonoids present in the extract. These results clearly indicated that ethanolic extract of the leaves of Mimosa pudica is effective against diarrhoeal disease
Key words: Anti-diarrhoeal activity, castrol oil-PGE2 induced diarrhoea, gastrointestinal motility, intestinal secretion, leaves
ethanolic extract, Mimosa pudica linn

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DOI: http://dx.doi.org/10.22377/ijgp.v5i1.179

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