Evaluation of anti-diarrhoeal potential of ethanolic extract of Mimosa pudica leaves

Md. Saifuddin Khalid, Shah Jinesh Kumar, D. K. Suresh, Rajnish Kumar Singh, I. V. Narasimha Reddy, Sunil Kumar


Diarrhoea is a major public health problem in developing countries and is said to be endemic in many regions of Asia. It is a leading cause of high degree of morbidity and mortality. The anti-diarrhoeal potential of the ethanolic extract of leaves of Mimosa pudica Linn (Mimosaceae) has been evaluated using several experimental models in Wistar albino rats. The ethanolic extract inhibited castor oil induced diarrhoea and PGE2 induced enteropooling in rats and has also reduced gastrointestinal motility after charcoal meal administration. The ethanolic extract at 200 and 400 mg/kg was showed significantly inhibited diarrhoea. There was a significant (P<0.001) dose-dependent decrease in the diarrhoea produced by all the three models in rats as compared to the standard drug. The anti-diarrhoeal property may be related to the tannin and flavonoids present in the extract. These results clearly indicated that ethanolic extract of the leaves of Mimosa pudica is effective against diarrhoeal disease
Key words: Anti-diarrhoeal activity, castrol oil-PGE2 induced diarrhoea, gastrointestinal motility, intestinal secretion, leaves
ethanolic extract, Mimosa pudica linn

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Rakhi G, Vairale MG, Chaudhari PR, Wate SR. Ethnomedicinal

plants used by gond tribe Bhandara District, Maharashtra in the

treatment of diarrhoea and dysentery. Ethnobotanical Leaflets


Fauci AS, Bravnwold E, Isselpacker K, Wilson JD, Kasper DL,

Hauser SL, et al. Harrison’s Principles of Internal Medicine. New

York: McGraw Hill Company; 1993. p. 236.

Virupaksha JH, Shivakumar H. Antiulcer activity of Fenugreek

seeds in aspirin plus pylorus ligation models. Indian J Nat Prod



html Webpage by Lynh-Diem Bui-Mimosa pudica.

Nadkarni KM. Indian Materia Medica. 3rd ed, vol. 1, Bombay:

Popular Prakashan. 2002. p. 1280-3.

India herbs – Ancient Remedies for Modern Times: Ayur State,

Doctor approved formula for prostate care.

Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy. 14th ed. Pune:

Nirali Prakashan; 2007. p. 297.

Khandelwal KR. Practical Pharmacognosy, 11th ed. Pune: Nirali

Prakashan; 2004. p. 149-56.

Veeraraghavan, Prema. Expert Consultant, CPCSEA, OECD

Guideline No.420, 2000.

Awouters F, Niemegeers CJE, Lenaerts FM, Janssen PA. Delay of

castor oil diarrhoea in rats: a new way to evaluate inhibitors of

prostaglandin biosynthesis. J Pharm Pharmacol 1978;30:41.

Mukherjee PK, Das J, Balasubramanian R, Sahakakali, Pal M,

Saha BP. Antidiarrhoeal evaluation of Nelumbo nucifera rhizome

extract. Indian J Pharmacol 1995;27:262-4.

Pazhani GP, Subramanian N, Arunchalam G, Hemalatha S,

Ravichandran V. Antidiarrhoeal potential of Elephantopus scaber

Linn leaf extract. Indian Drugs 2001;38:269.

Mukherjee PK, Saha K, Murugesan T. Screening of anti-diarrhoeal

profile of some plant extracts of a specific region of West Bengal,

India. J Ethnopharmacol 1998;60:85-9.

Galvez J, Zarzuelo A, Crespo ME. Antidiarrhoeal activity of

Euphorbia bitra extract and isolation of an active flavonoids

constituent. Planta Med 1993;59:333-6.

Okudo T, Yoshoda T, Hatano T. New methods of analyzing tannins.

J Nat Prod 1989;52:1-31.

Evans WC, editor. Pharmacognosy, Singapore: Har Court Brace

and Co. Pvt. Ltd.; 1997.

Di Carlo G, Autore G, Izzo AA. Inhibition of intestinal motility

and secretion by flavonoids in mice and rats: Structure activity

relationships. J Pharm Pharmacol 1993;45:1054-9.

Rao VS, Santos FA, Sobreika TT. Investigation on the gastroprotective

and antidiarrhoeal properties of ternatin: A tetrmethoxyflavone

from Egletes viscose. Planta Med 1997;63:146-9.

DOI: https://doi.org/10.22377/ijgp.v5i1.179


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