Comparing the anti-arthritic activities of the plants Justicia gendarussa Burm F. and Withania somnifera Linn

Jaijesh Paval, Srinivasan Keloth Kaitheri, Bhagath Kumar Potu, Sreejith Govindan, Raju Suresh Kumar, Sareesh Naduvil Narayanan, Sudheer Moorkoth


The aim of this study was to compare the anti-arthritic activities of the plants Justicia gendarussa and Withania somnifera. Arthritis
is induced in male albino rats using Freund’s complete adjuvant and bovine type II collagen. Leaves of J. gendarussa and roots of
W. somnifera were powdered and extracted with ethanol (95%) using the soxhlet method. The effect of these plant extracts on
arthritic rats were assessed by various blood parameters and also by taking the change in paw volume. The plants J. gendarussa and
W. somnifera suppressed the anti-arthritic changes induced in rats and the results were statistically significant.
Key words: Arthritis, collagen, paw volume, plant extract

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