Anti-inflammatory activity of methanolic extract of Bambusa vulgaris leaves

William M. Carey, Jeevan Mani Babu Dasi, Nimmagadda V. Rao, Krishna Mohan Gottumukkala

Abstract


Bambusa vulgaris, commonly known as “Bamboo,” possesses various pharmacological activities including anti-inflammatory activity. The present study is designed to investigate anti-inflammatory effect of methanolic extract of B. vulgaris (MEBV) on rats and mice. The anti-inflammatory effect is investigated employing acute inflammatory models: formaldehyde-induced paw edema, acetic
acid-induced vascular permeability, subacute anti-inflammatory model: cotton pellet granuloma, estimation of plasma MDA and
carrageenan-induced peritonitis. MEBV (100, 200 and 400 mg/kg, p.o) exhibited a dose-dependent and significant inhibition (P <0.01) in all the experimental models. Preliminary phytochemical screening revealed the presence of flavonoids, carbohydrates, glycosides, proteins, and alkaloids. The extract produces no mortality in the dose up to 2000 mg/kg, p.o. The results obtained suggest marked anti-inflammatory activity of the MEBV and support the traditional use of this plant in some painful and inflammatory conditions.
Key words: Bambusa vulgaris, poaceae, vascular permeability, granuloma, peritonitis, edema

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DOI: http://dx.doi.org/10.22377/ijgp.v3i3.91

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