Antifertility activity of ethanolic extracts of Plumbago indica and Aerva lanata on albino rats

R. V. Savadi, K. R. Alagawadi

Abstract


The ethanolic extract of roots of Plumbago indica and aerial parts of Aerva lanata were evaluated for antifertility activity using antiimplantation, abortificient, and motility of rat spermatozoa (in-vitro) models. The anti-implantation effect seems to be depending on the dose as well as the initiation of treatment on specific days of pregnancy. P. indica has showed percentage pre-implantation loss of 40% and 50% against control at the doses of 200 and 400 mg/kg b/w. Percentage pregnancy failure among treated groups was 60% and 70% at the doses of 200 and 400 mg/kg b/w, whereas A. lanata has shown pre-implantation loss of 20% and 30% against
control at the dose of 200 and 400 mg/kg b/w, respectively. Percentage pregnancy failure among treated groups was 30% and 40% at the dose of 200 and 400 mg/kg b/w, respectively. Both P. indica and A. lanata at a concentration of 10% have shown no motility of rat spermatozoa within 60 seconds.
Key words: Plumbago indica, Aerva lanata, anti-implantation, abortifacient, spermatozoa

Full Text:

PDF

References


Dhal NK,Rout NC, Thiranavoukkarasu M. A specific case study

for birth control among the jain tribe of orissa. Ethnobotany

;12:27-8.

Afaq SH, Tajuddin S, afridi R. Some lesser know uses and

Pharmacognosy. Ethnobotany 1991;05:37.

Chandra S, Shastri MS. Chemical constituents of Aerva lanata.

Fitotherpia 1990;61:188-90.

Zapesochnaya G, Kurkin V, Okhavow V, Hiroshnikov A. Canthin-

-one and β-Carboline alkaloids from Aerva lanata. Planta Medica

;37:192-4.

Organization for Economic Co-operation and Development. Joint

meeting of the chemicals committee and the working party on

chemicals, pesticides and biotechnology. 2001.

Prathiba D, Subhash P, Aruna K. Anti-implantation and abortive

effects of Plumbago zylanica in Albino rats. Indian J Comp Anim

Physiol 1988;6:23-7.

Sur TK, Pandit S, Praminik T, Bhattacharyya D. Effect of Aegle

marmalos leaf on rat sperm motility an in-vitro study. Indian J

Pharmacol 2002;34:276-7.

Gupta RS, Batnagar AK, Joshi YC, Sharma R, Sharma A.

Suppression of fertility in male albino rats following α-Amyrin

aetate administration. Pharma Biol 2004;42:98-104.




DOI: http://dx.doi.org/10.22377/ijgp.v3i3.90

Refbacks

  • There are currently no refbacks.