Antihyperlipidemic activity of Sphaeranthus indicus on atherogenic diet induced hyperlipidemia in rats

V. V. Pande, Sonal Dubey


The present study was designed to investigate the Antihyperlipidemic activity of alcoholic extract of Sphaeranthus indicus L. flower heads in atherogenic diet induced hyperlipidemia. Sphaeranthus indicus extract was administered in a dose of 500 mg/kg/day, p.o. for eight days. Marked decrease in body weight, total cholesterol, triglyceride, and low-density lipoprotein and very low density lipoprotein whereas significant increases in the level of high-density lipoprotein were obtained after treatment with Sphaeranthus indicus extract. The present work indicates that, Sphaeranthus indicus extract in a dose of 500 mg/kg/day effectively suppressed the atherogenic diet induced hyperlipidemia in rats, suggesting the potential protective role in atherosclerosis.
Key words: Sphaeranthus indicus, atherogenic diet, hyperlipidemia

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