Anti-diabetic activity of leaf extract of Tridax procumbens

Abstract

A study of ancient literature indicates that diabetes was fairly well known and well conceived as an entity in India. Plant-based drugs have been used against various diseases since a long time. Th e nature has provided abundant plant wealth for all the living creatures, which possess medicinal virtues. Th e essential values of some plants have long been published, but a large number of them have remained unexplored to date. Th erefore, there is a necessity to explore their uses and to conduct pharmacognostic and pharmacological studies to ascertain their therapeutic properties. In fact, nowadays, diabetes is a global problem. Hence, the present study aims to open new avenues for the improvement of medicinal uses of Tridax procumbens (Compositae) for the selected area for diabetes. Another
important objective of such a study is to bring the anti-diabetic medicinal plants sector on a fi rm scientifi c footing, raise awareness and add value to the resource. Dried aqueous, alcoholic, and petroleum ether (60-80°C) extracts of leaves of Tridax procumbens were subjected for hypoglycaemic activity in Wistar rats (150-200 g). Blood sugar level was determined using digital glucometer. Th e oral administration of leaf extracts at doses of 200 mg kg−1 lead to a signifi cant blood glucose reduction. Th is laid the foundation to study  the active compounds of such anti-diabetic plants that are responsible for the hypoglycemic activities. It also proves the traditional
claim of Mandesh region with regard to Tridax procumbens for its anti-diabetic activity.
Key words: Alloxan-induced diabetes, hypoglycaemic activity, Tridax procumbens