Anti-diabetic activity of leaf extract of Tridax procumbens

Durgacharan A Bhagwat, Suresh G. Killedar, Rahul S. Adnaik

Abstract


A study of ancient literature indicates that diabetes was fairly well known and well conceived as an entity in India. Plant-based drugs have been used against various diseases since a long time. Th e nature has provided abundant plant wealth for all the living creatures, which possess medicinal virtues. Th e essential values of some plants have long been published, but a large number of them have remained unexplored to date. Th erefore, there is a necessity to explore their uses and to conduct pharmacognostic and pharmacological studies to ascertain their therapeutic properties. In fact, nowadays, diabetes is a global problem. Hence, the present study aims to open new avenues for the improvement of medicinal uses of Tridax procumbens (Compositae) for the selected area for diabetes. Another
important objective of such a study is to bring the anti-diabetic medicinal plants sector on a fi rm scientifi c footing, raise awareness and add value to the resource. Dried aqueous, alcoholic, and petroleum ether (60-80°C) extracts of leaves of Tridax procumbens were subjected for hypoglycaemic activity in Wistar rats (150-200 g). Blood sugar level was determined using digital glucometer. Th e oral administration of leaf extracts at doses of 200 mg kg−1 lead to a signifi cant blood glucose reduction. Th is laid the foundation to study  the active compounds of such anti-diabetic plants that are responsible for the hypoglycemic activities. It also proves the traditional
claim of Mandesh region with regard to Tridax procumbens for its anti-diabetic activity.
Key words: Alloxan-induced diabetes, hypoglycaemic activity, Tridax procumbens

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References


Ivorra MD, Paya M, Villar A. A review of natural products

and plants as potential antidiabetic drugs. J Ethnopharmacol

;27:243-75.

World Health Organization. Department of Noncommunicable

Disease Surveillance. DeÞ nition, Diagnosis and ClassiÞ cation

of Diabetes Mellitus and its Complications. Geneva: WHO;

Saraf S, Dixit VK. Hepatoprotective activity of Tridax procumbens -

Part II. Fitoterapia 1991;62:534-6.

Ali M, Ravinder E, Ramachandran R. A new ß avonoid from the

aerial parts of Tridax procumbens. Fitoterapia 2001;72:313-5.

Saraf S, Pathak AK, Dixit VK. Hair growth promoting activity of

Tridax procumbens. Fitoterapia 1991;62:495-8.

Pathak AK, Saraf S, Dixit VK. Hepatoprotective activity of Tridax

procumbens - Part I. Fitoterapia 1991;62:307-13.

Sokeng SD, Rokeya BM, Mostafa, et al. Antihyperglycemic eff ect of

Bridelia Ndellensis ethanol extract and fractions in streptozotocininduced

diabetic rat. Afr J Trad CAM 2005;2:94-102.

Knudsen LF, Curtius JM. The use of the angular transformation

in biological assays. J Am State Assoc 1947;42:282.

Vogel GH. Drug Discovery and Evaluation, 2nd ed. 2002. p. 950.

Onunkwo GC, Akah PA, Udeala OK. Studies on B. ferruginea

leaves (I), Stability and hypoglycemic actions of the leaf extract

tablets. Phytother Res 1996;10:418-20.

Lenzen S, Panten U. Alloxan: History and mechanism of action.

Diabetologia 1988;31:337-42.

Oberley LW. Free radicals and diabetes. Free Rad Biol Med

;5:113-24.

Jorns A, Munday R, Tiedge M, Lenzen S. Comparative toxicity

of alloxan, N-alkyl-alloxans and ninhydrin to isolated pancreatic

islets in vitro. J Endocrinol 1997;155:283-93.

Ledoux SP, Woodley SE, Patt on NJ, Wilson LG. Mechanism of

notrosourea-induced β-cells damage-alterations in DNA. Diabetes

;35:866-72.

Szkudelski T. The mechanism of Alloxan and Streptozotocin action

in B cells of the rat pancreas. Physiol Res 2001;50:537-46.

Ravikumar V, Kanchi Subramanian Shivashangari, Devaki T,

Eff ect of Tridax procumbens on liver antioxidant defense system

during lipopolysaccharide-induced hepatitis in D-galactosamine

sensitised rats. Molecular and Cellular Biochemistry, 2005;269:

-136.




DOI: https://doi.org/10.22377/ijgp.v2i2.46

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