The essential oil from Vanillosmopsis arborea Baker (Asteraceae) presents antinociceptive, antiâ€inflammatory, and sedative effects

Abstract

Background: The essential oil from Vanillosmopsis arborea (EOVA) Baker is rich in (â€)â€Î±â€bisabolol. Investigations demonstrated its
gastroprotective, larvicidal, and visceral antinociceptive activities. Aims: The present study aimed to elucidate the antinociceptive,
antiâ€inflammatory and sedative properties of the EOVA Baker in mice. Materials and Methods: The antinociceptive and
antiâ€inflammatory activities were assessed using the abdominal constriction, formalin and carrageenanâ€induced paw edema models,respectively. The sedative property was detected by the openâ€field and sleeping time tests. Results were analyzed by ANOVA, followed by Studentâ€Newman–Keuls test. Results: EOVA, after intraperitoneal administration, produced an inhibition of the acetic acidâ€induced writhing in mice. In addition, the same doses were able to inhibit both the early and late phases of the formalinâ€induced nociception. EOVA produced inhibition in the carrageenanâ€induced edema model, reduced the spontaneous motor activity and prolonged the sleeping time induced by pentobarbital. Conclusion: The experimental data demonstrated that EOVA showed antinociceptive,antiâ€inflammatory, and sedative activities.

Key words: Anti-inflammatory agents, antinociceptive agents, essential oils, sedative effect