Development, evaluation, and biological characterization of antidiabetic oral polyherbal tablets

Abstract

Introduction: Design and development of oral polyherbal tablet formulation is still a challenge in modern
pharmaceutics. The oral polyherbal tablet formulation presents many technical problems to the pharmacists. The
main objective of the present study was to develop, evaluate, and biological characterized antidiabetic tablets.
Material and Methods: Here, we used potentially active Alstonia scholaris, Pterocarpus marsupium, and
Embelia ribes which are the medicinal plants or herbs used for the antidiabetic activity. In this work, polyherbal
tablets were prepared using hydroalcoholic extracts of A. scholaris (leaves and material), P. marsupium (bark),
and E. ribes (seeds) by the compression method for the treatment of diabetes. Polyherbal tablets were prepared
and evaluated by weight variation, hardness, friability, and disintegration time. Result: The optimized formulation
was investigated the antidiabetic activity in streptozotocin-induced diabetic rats fasting blood glucose level
was measured on 0, 7, and 15 days. We find that evaluation parameters of polyherbal formulation were within
acceptable pharmacopoeial limits. Conclusion: No marked changes were noticed in all the evaluated parameter
during study. The laboratory scale preparation of polyherbal tablet formulation may be used as stable, solid dosage
form and this work done may help in progress of field of antidiabetic activity of polyherbal tablet formulation.