Spectral kinetic method and its applications in the evaluation of gabapentin

H. N. K. AL-Salman


Context: A new and highly sensitive method for the determination of gabapentin (GBP), this method is of high importance in the assessment of GBP and other pharmaceutical preparations. GBP is a widely used antibiotic. There is a big challenge of analysis of anti-epilepsy drugs due to their instability and sensitivity to various conditions. The simple, sensitive, precise, and kinetic spectroscopy method was used to measure GBP in some pharmaceuticals developed and validated. Objective: The objective of the study was to develop a simple, sensitive, accurate, and kinetic spectroscopy method for the measurement of GBP in a pharmaceutical product. Materials and Methods: The current method was based on the spectral kinetic examination of epileptics (GBP) with potassium permanganate in alkaline medium at room temperature. Absorption of the stained manganese ions of the product was absorbed at 605 nm. Results: The concentration of GBP was calculated using the calibration equation for the time method and the initial rate method. The above method is used to determine GBP from 2.0 to 20 μg/mL. The BER Act was applied to roads within the range of concentrations used for analysis. The limit of quantification and limit of detection, equal to 0.640 and 1.940, were calculated, respectively. The relative standard deviation values was found to be 0.345% and Recovery values were 99.38 and 0.50%, respectively. Conclusion: The proposed and developed method is sensitive, accurate, and tolerable and can be used for the routine analysis of GBP in various pharmaceuticals. The proposed method was successfully applied to the determination of the drug jabapentin in the pharmaceuticals and the validation of the statistical data. The results were compared to the reference method showed good compatibility.

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DOI: https://doi.org/10.22377/ijgp.v12i04.2208


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