Psychopharmacological investigations on the benefits of Ageratum conyzoides in the modulation of neurodegenerative disorder of Alzheimer’s type

S. M. Biradar, Hanumanthachar K. Joshi


Alzheimer’s disease is a neurodegenerative disease of the central nervous system that leads to dementia, behavioural and
cognitive impairments. The study was aimed to investigate the effect of Ageratum conyzoides (AC) on memory and whole brain
acetylcholinesterase activity in mice by employing the exteroceptive behavioural models like elevated plus maze and Morris water maze and interoceptive behavioural models like scopolamine and natural ageing inducing amnesia. AC (250, 500 and 750 mg/kg, orally p.o.) produced a dose-dependent improvement in learning capability and retention memory of both young and aged mice. Furthermore, it also reversed the scopolamine (0.4 mg/kg, i.p.) and natural ageing-induced amnesia in young and old mice respectively. One more important thing about AC is that it increases the acetylcholine indirectly by reducing the whole brain acetylcholinestrease activity. Hence AC may have a beneficial effect in the management of neurodegenerative disorder of
Alzheimer’s type.
Key words: Acetylcholinestrease, aged mice, ageratum conyzoides, scopolamine

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