Psychopharmacological investigations on the benefits of Ageratum conyzoides in the modulation of neurodegenerative disorder of Alzheimer’s type

S. M. Biradar, Hanumanthachar K. Joshi

Abstract


Alzheimer’s disease is a neurodegenerative disease of the central nervous system that leads to dementia, behavioural and
cognitive impairments. The study was aimed to investigate the effect of Ageratum conyzoides (AC) on memory and whole brain
acetylcholinesterase activity in mice by employing the exteroceptive behavioural models like elevated plus maze and Morris water maze and interoceptive behavioural models like scopolamine and natural ageing inducing amnesia. AC (250, 500 and 750 mg/kg, orally p.o.) produced a dose-dependent improvement in learning capability and retention memory of both young and aged mice. Furthermore, it also reversed the scopolamine (0.4 mg/kg, i.p.) and natural ageing-induced amnesia in young and old mice respectively. One more important thing about AC is that it increases the acetylcholine indirectly by reducing the whole brain acetylcholinestrease activity. Hence AC may have a beneficial effect in the management of neurodegenerative disorder of
Alzheimer’s type.
Key words: Acetylcholinestrease, aged mice, ageratum conyzoides, scopolamine

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References


Heo H, Shin Y, Cho W, Choi Y, Kim H, Kwon YK. Memory

improvement in ibotenic acid induced model rats by extracts of

Scutellariabaicalensis. J Ethnopharmacol 2009;122:20-7.

Andrade C, Chandra JS. Anti-amnestic properties of Brahmi and

Mandookaparni in a rat model. Indian J Psychiatry 2006;48:232-7.

Kulkarni MP, Juvekar AR. Effect of Alstoniaschollaris (Linn.) R.Br.

on stress and cognition in mice. Ind J Exp Biol 2009;47:47-52.

Vasudevan M, Parle M. Pharmacological actions of Thespesiapopulnea

relevant to alzheimer ’s disease. Phytomedicine 2006;13:

-87.

Brewer GJ. Age-related toxicity to lactate, glutamate, and β-amyloid

in cultured adult neurons. Neurobiol Aging 1998;19:561-8.

Smith JV, Luo Y. Elevation of oxidative free radicals in Alzheimer’s

disease models can be attenuated by Ginkgo biloba extract EGb

J Alzheimers Dis 2003;5:287-300.

Wood AJ. Drug therapy: Alzheimer’s disease. N Engl J Med

;351:56-67.

Lather A, Gupta V, Tyagi V, Kumar V, Garg S. Phytochemistry and

pharmacological activites of Bersamaenglerianaguerke-an overview.

International research journal of pharmacy 2010;1:89-94.

Adjanohoun EJ, Ahyi AMR, Ake-Assi L. M´edicinetraditionelleet

pharmacop´ee, 1988.

Durodola JI. Antibacterial property of crude extracts from a herbal

wound healing remedy - Ageratum conyzoides L. Planta Med

;32:388-90.

Galati EM, Miceli N, Taviano MF, Sanago R, Raneri F. Antiinflammatory

and antioxidant activity of Ageratum conyzoides.

Pharm Biol 2001;31:336-9.

Shirwaikar A, Bhilegoankar PM, Malini S, Sherathkumar J.

The gastroprotective activity of the ethanol extract of

Ageratum conyzoides. J Ethnopharmacol 2003;86:117-21.

Nyunaï N, Njikam N, Abdennebi el H, Mbafor JT, Lamnaouer D.

Hypoglycaemic and antihyperglycaemic activity of Ageratum

conyzoides L. in rats Afr J Tradit Complement Altern Med

;6:123-30.

Khandelwal KR. Practical Pharmacognosy. Pune: NiraliPrakashan;

p. 149-56.

Ghosh MN. Fundamentals of Experimental Pharmacology. 2nd ed.

Calcutta: Scientific Book Agency; 1984. p. 154-8.

Turner MA. Screening Methods in Pharmacology. New York:

Academic press; 1965. p. 26.

Parle M, Dhingra D, Kulkarni SK. Improvement of mouse memory

by Myristicafragrans seeds. J Med Food 2004;7:157-61.

Ellman GL, Courtney KD, Andres V Jr, Feather-Stone RM. A new

and rapid colourimetric determination of acetylcholinestrase

activity. Biochem Pharmacol 1961;7:88-95.

Parle M, Dhingra D, Kulkarni SK. Neuromodulators of learning

and memory. Asia Pac J Pharmacol 2004;16:89-99.

Joseph H, Sellin, Pasricha PJ. Pharmacotherapy of inflammatory

bowel disease. In: Brunton LL, Lazo JS, Parker KL, editors.

Goodman and Gilman’s The Pharmacological Basis of Therapeutics.

th ed. New York: McGraw Hill; 2006. p. 1009-19.

Sato A, Sato Y, Uchida S. Regulation of cerebral cortical blood flow

by the basal forebrain cholinergic fibers and aging. AutonNeurosci

;96:13-9.

Dhingra D, Parle M, Kulkarni SK. Comparative brain cholinesteraseinhibiting

activity of Glycyrrhizaglabra, Myristicafragrans,

ascorbic acid, and metrifonate in mice. J Med Food 2006;9:281-3.

Joshi H, Parle M. Zingiberofficinale: Evaluation of its nootropic

effect in mice. Afr J Trad CAM 2006;3:64-74.

Ghelardini C, Galeotti N, Bartolini A, Furukawa S, Nitta A,

Manetti D, et al. Memory facilitation and stimulation endogenous

nerve growth factor synthesis by the acetylcholine releaser PG-9.

Jpn J Pharmacol 1998;78:245-51.

Peng WH, Hsich MT, Wu CR. Effect of long-term administration of

berberine of scopolamine-induced amnesia in rats. Jpn J Pharmacol

;74:261-6.

Rao SK, Andrade C, Reddy K, Madappa KN, Thyagarajan S,

Chandra S. Memory protective effect of indomethacin against

electroconvulsive shock-induced retrograde amnesia in rats. Biol

Psychiatry 2002;51:770-3.

Stephan A, Laroche S, Davis S. Learning deficits and dysfunctional

synaptic plasticity induced by aggregated amyloid deposits in the

dentate gyrus are rescued by chronic treatment with indomethacin.

Eur J Neurosci 2003;17:1921-7.

Berr C. Oxidative stress and cognitive impairment in the elderly.

J Nutr Health Aging 2002;6:261-6.

Joshi H, Parle M. Effect of piperine on memory and behaviour

mediated via monoamine neurotransmitters. J Tradit Med

;23:39-43.

Moura AC, Silva EL, Fraga MC, Wanderley AG, Afiatpour P,

Maia MB. Anti inflammatory and chronic toxicity study of the leaves

of Ageratum conyzoides L. in rats. Phytomedicine 2005;12:138-42.




DOI: http://dx.doi.org/10.22377/ijgp.v5i3.204

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