Recent development in novel drug delivery systems of herbal drugs

Mayank Chaturvedi, Manish Kumar, Amit Sinhal, Alimuddin Saifi


Novel technologies have been developed recently for drug delivery systems. The use of herbal formulations for novel drug delivery systems is more advantageous and has more benefits compared to others. The use of liposome, ethosome, phytosomes, emulsion, microsphere, solid lipid nanoparticles of herbal formulation has enhanced the therapeutic effects of plant extracts. With the use of all these, targeted delivery of the formulation is achieved, due to which the formulation demonstrates effect on the site, and the bioavailability of the formulation is also increased. With these novel drug delivery systems, the actives and extracts which are used in
herbal formulations demonstrate enhancement in stability, sustained release of formulation, protection from toxicity and improved therapeutic efficacy. The main purpose of developing alternative drug delivery technologies is to increase efficiency of drug delivery and safety in the process of drug delivery and provide more convenience for the patient. The present paper includes information about novel formulations of herbal formulations.
Key words: Emulsion, ethosome, herbal drugs, liposome, microsphere, nanoparticles, solid lipid nanoparticle

Full Text:



Harro H. GMBH Technology for New Drug Delivery Systems

Business brieping; Pharmacogenerics 2003.

Hikino H, Kiso Y, Wagner H, Fiebig M. Antihepatotoxic actions

of flavonolignans from Silybum marianum fruits. Planta Med


Sowjanya JN, Kumar YK, Das S. Phytosome: A novel entity in

herbal delivery system. Int J Pharm Res Dev 2010;2:153-64.

Patel J, Patel N. An overview of phytosome as an advanced drug

delivery system. Asian J Pharma Sci 2009;4:363-71.

Kuntal M, Mukherjee K, Ahamed H. Enhanced therapeutic benefit

of Quercitin- phospholipid complex in carbon tetrachloride

induced acute liver injury in rats: A comparative study. Iran J

Pharmacol Ther 2005;4:84-90.

Yue PF, Yuan HL, Li XY, Yang M, Zhu WF. Process optimization,

characterization and evaluation in vivo of oxymatrine-phospholipid

complex. Int J Pharm 2010;387:139-46.

Naik SR, Panda VS. Hepatoprotective effect of Ginkgoselect

Phytosome in rifampicin induced liver injury in rats: evidence of

antioxidant activity. Fitoterapia 2008;79:439-45.

Sikarwar MS, Sharma S, Jain AK, Parial SD. Preparation,

characterization and evaluation of Marsupsin-phospholipid

complex. AAPS PharmSciTech 2008;9:129-37.

Pathan R, Bhandari U. Preparation and characterization of

embelin-phospholipid complex as effective drug delivery tool. J

Incl Phenom Macrocycl Chem 2010.

Semalty A, Semalty M, Singh D. Supramolecular phospholipid

polyphenolics interection: The phytosome strategy to improve

the bioavailabilty of phytochemicals J Incl Phenom Macrocycl

Chem 2010;67:253-60.

Kidd P, Head K. A review of the bioavailability and clinical efficacy

of milk thistle phytosome: a silybin-phosphatidylcholine complex

(Siliphos). Altern Med Rev 2005;10:193-203.

JuQun XI, Guo R. Studies on molecular interection between

puerarin and pc liposome. Chinese Sci Bull 2007;52:2612-7.

Ajazuddin, Saraf S. Applications of novel drug delivery system

for herbal formulations. Fitoterapia 2010;81:680-9.

Chen C. Inhibiting the vascular smooth muscle cells proliferation

By EPC and DPPC liposome encapsulated magnalol. J Chin Inst

Chem Eng 2008;39:407-411.

Chen J, Chen Z, Wang W. Ammonium sulphate gradient loading

of brucine into liposome: effect of phospholipid composition on

entrapment efficiency and physicochemical properties in vitro.

Drug Dev Ind Pharm 2010;36:245-253.

Ghosh D, Ghosh S, Sarkar S, Ghosh A, Das N, Das Saha K, et al.

Quercetin in vesicular delivery systems: evaluation in combating

arsenic-induced acute liver toxicity associated gene expression in

rat model. Chem Biol Interact 2010;186:61-71.

Hazra B, Kumar B, Biswas S, Pandey BN, Mishra KP. Enhancement

of the tumour inhibitory activity, in vivo, of diospyrin, a plantderived

quinonoid, through liposomal encapsulation. Toxicol

Lett 2005;157:109-17

Gortzi O, Lalas S, Chinou L. Re-evaluation of bioactivity and

antioxidant activity of myrtuscommunis extract before and after

encapsulation in liposome. Eur Food Res Technol 2008;226:583-90

Fadda AM, Sinico C, Lai F, Logu AD. Liposomal incorporation of

artimisia arborescenceL. Essential oil and in vitro antiviral activity.

Eur J Pharma Biopharma 2005;59:161-8.

Rong G, JuQun X. Studies on molecular interection between

puerarin and PC liposomes. Chinese Sci Bull 2007;52:2612-7

Vyas SP, Khar RK. Targeted and controlled drug delivery novel

carrier systems. Edn -IInd, CBS publishers and distributors, N.

Delhi: 2002. p. 15-6, 346-8.

Prabhu N, Gowari K, Raj D. Synthesis of silver phyto

nanoparticles and their antibacterial activity. Digest.J.Nano.


Chang CH, Huang WY, Lai CH, Hsu YM, Yao YH, Chen TY,

et al. Development of novel nanoparticles shelled with heparin

for berberine delivery to treat Helicobacter pylori. Acta Biomater


Kumari A, Yadav SK, Pakade YB, Kumar V, Singh B, Chaudhary A,

et al. Nanoencapsulation and characterization of Albizia chinensis

isolated antioxidant quercitrin on PLA nanoparticles. Colloids

Surf B Biointerfaces 2011;82:224-32

Wang F, Zhou L, Gu F. Characterization of anticancer hypocrellin

A encapsulated with silica nanoparticles. J Therm Anal Calorim


Jia L, Zhang D, Li Z, Duan C, Wang Y, Feng F, et al. Nanostructured

lipid carriers for parenteral delivery of silybin: Biodistribution

and pharmacokinetic studies. Colloids Surf B Biointerfaces


Leonard K, Ahmmad B, Okamura H, Kurawaki J. In situ green

synthesis of biocompatible ginseng capped gold nanoparticles with

remarkable stability. Colloids Surf B Biointerfaces 2011;82:391-6

Fu ZY, Zhang JY, Wang WM, Wang H. Microencapsulation of

radiax saliva miltiorrhiza nanoparticles by spray drying. Powder

Technol 2008;184:114-21

Xu HW, Fang Q, Wang JS, Wang PM. Study on preparation of

paclitaxel loadedPEG-PLGA nanoparticles in vitro experiment

China Hospital Pharmacy Journal 2008;28:11-4.

Cui F, Wang Y, Wang J, Feng L, Ning K. Preparation of an entericsoluble

solid-state emulsion using oily drugs. Int J Pharma


Sun HW, Ouyang WQ. The preparation of neem oil microemulsion

(Azdirachta Indica) and the comparission of acaricidal time

between neemoil microemulsion and other formulation in vitro. J

Shanghai Jiao Tong Univy (Agric Sci) 2007;1:60-5.

Sun SW, Yeh PC. Analysis of rhubarb anthraquinones and

bianthrones by microemulsion electrokinetic chromatography. J

Pharma Biomed Ana 2005;36:995-1001

Ruan J, Liu J, Zhu D, Gong T, Yang F, Hao X, et al. Preparation

and evaluation of self-nanoemulsified drug delivery systems

(SNEDDSs) of matrine based on drug-phospholipid complex

technique. Int J Pharma 2010;386:282-90.

Vicentini FT, Simi TR, Del Ciampo JO, Wolga NO, Pitol DL,

Iyomasa MM, et al. Quercetin in w/o microemulsion: In vitro

and in vivo skin penetration and efficacy against UVB-induced

skin damages evaluated in vivo. Eur J Pharm Biopharm 2008;69:


Cui F D, Yin Y,Choi M K,Chung S. Docetaxel microemulsion for

enhanced bioavailability: Preparation and in vitro and in vivo

evalution. J Cont Rel 2009; 140: 86-94

Wong HL, Bendayan R, Rauth AM, Li Y, Wu XY. Chemotherapy

with anticancer drugs encapsulated in solid lipid nanoparticles.

Adv Drug Deliv Rev 2007;59:491-504.

Muller RH, Wissin SA. Encycbpedia Nanosci Nanotechnol


Scarfato P, Avallone E, Iannelli P, Aquino RP. Qucertin microsphere

by solvent evaporation: preparation characterization and release

behaviour J Appl Polymer Sci 2008;109:2994-3001

Cheng-Bai, Di Z, Xia C, Dan J. Preparation and characterization

of biodegradedable polylactide microsphere encapsulating

Ginsenoside Rg3 Chem Res Chinese Univ 2008;24:588-91

Natrajan V, Madhan B, Sehgal P. Formulation and evalution

of qucertin polycaprolactone microsphere for the treatment

of Rheumatoid arthritis. J Pharm Sophora alopecuroides sci.


Han X, Wang S, Yang L. Study of the preparation of sustained

release microsphere containing zedoary turmeric oil by the

emulsion solvent diffusion method and evalution of the self

emulsification and bioavailability of oil. Colloids Surf B 2006;


Xio L, Zang Y H, Jin X H. Preparation of floating rutin aliginate

chitosan microsphere. Chinese traditional and herbal drugs


Touitou E. Godin B. Ethosome novel vesicular carrier for enhanced

delivery: characterization and skin penetration properties. J Cont

Rel 2000;3:403418

Zhou Y, Wei Y, Liu H, Zhang G, Wu X. Preparation and in vitro

evaluation of ethosomal total alkaloids of Sophora alopecuroides

loaded by a transmembrane pH-gradient method. AAPS

PharmSciTech 2010;11:1350-8

Zhaowu Z, Xiaoli W, Yangde Z, Nianfeng L. Preparation of

matrine ethosome, its percutaneous permeation in vitro and antiinflammatory

activity in vivo in rats. J Liposome Res 2009;19:155-62.

Zhaowu Z, Xiaoli W, Yangde Z, Nianfeng L. Preparation of

matrine ethosome, its percutaneous permeation in vitro and antiinflammatory

activity in vivo in rats. J Liposome Res 2009;19:155-62.

Pople PV, Singh KK. Development and evaluation of topical

formulation containing solid lipid nanoparticles of vitamin A.

AAPS Pharm Sci Tech 2006;7:91.

Gande S, Kopparam M, Vobalaboina V. Preparation characterization

and in vitro and in vivo evalution of lovastatin solid lipid

nanoparticle AAPS Pharm Sci Tech 2007;8:1-8.

Kakkar V, Singh S, Singla D, Sahwney S, Chauhan AS, Singh

G, et al. Pharmacokinetic applicability of a validated liquid

chromatography tandem mass spectroscopy method for orally

administered curcumin loaded solid lipid nanoparticles to rats. J

Chromatogr B Analyt Technol Biomed Life Sci 2010;878:3427-31

Nayak AP, Tiyaboonchai W, Patankar S, Madhusudhan B.

Curcuminoids loaded lipid nanoparticles: Novel approach to treat

malaria treatment. Amsterdam: Elsevier B.V; 2010.

Daud A. Latest bibliographic data on file with International

Bureau, Pub. No.WO/2008/059522

Bayarski Y. Available from:

patches/NDDS/Herbal drugs. [cited in 2010].

Transdermal patch. Available from: http://www.levinhealthcare.

com. [cited in 2010].

Wang D, Connock M, Barton P, Fry-Smith A, Aveyard P, Moore D.

Cut down to quit with nicotine replacement therapies in smoking

cession: A systemic review of effectiveness and economic analysis

Health Technol Assess 2008;12:1-35.



  • There are currently no refbacks.