Preliminary investigation of patchaippasali mucilage (Basella alba) as tablet binder

G. Ramu, G. Krishna Mohan, K. N. Jayaveera


Basella alba leaf mucilage was investigated as a binder in paracetamol tablets prepared by wet granulation method. Mucilage at four levels (concentrations of mucilage binders: 4, i.e., 2.5, 5, 7.5 and 10% w/w) were studied. No significant work has been reported to use it as a tablet binder. The evaluation of granules showed 0.62 to 0.76 mm granule size, 28°47' to 30°27' angle of repose and 31.57 to 23.45% fines. Moisture content of the different granulations was less than 1%. The tablets were prepared and evaluated for average weight and weight variation, thickness, content uniformity, hardness, friability, disintegration time and in vitro dissolution profiles. All the batches of tablets exhibited good uniformity in content. The hardness was within the range of 4.5 to 5.5 kg/cm2. The hardness was increased and friability decreased with the increasing concentration of binding agent. The disintegration time also increased with increasing binder concentrations. The evaluation of tablet showed 0.434 to 0.410% friability, 9 to 18 minutes disintegration time
and the drug release was more than 70% in 60 minutes. Tablets at 7.5% w/w binder concentration showed more optimum results as tablet binder. The B. alba mucilage was found to be good as a binder to paracetamol tablets.
Key words: Basella alba, binder, mucilage, paracetamol, patchaippasali

Full Text:



Pilpel N, Otuyemi SO, Kurup TR. Factors affecting the

disintegration and dissolution of chloroquine phosphate/starch

tablets. J Pharm Pharmacol 1978;30:214-9.

Evans WC. Trease and Evan’s Pharmacognosy. London: WB

Saunders Company; 14th ed. 2001. p. 210.

Baveja SK, Rao KV, Arora J. Examination of natural gums and

mucilages as sustaining materials in tablet dosage forms-II. Indian

J Pharm Sci 1989;51:115-8.

Facciola S. Cornucopia: A source book of edible plants. Kampong

Publications; vol. 2, 1990. p. 183-7.

Duke JA, Ayensu ES. Medicinal Plants of China Reference

Publications, Inc; 1985.

Kulkarni GT, Gowthamarajan K, Brahmajirao G, Suresh B.

Evaluation of binding properties of selected natural mucilages. J

Sci Ind Res (India) 2002;61:529-32.

Panda DS, Choudhury NS, Yedukondalu M, Si S, Gupta R.

Evaluation of gum of Moringa oleifera as a binder and release

retardant in tablet formulation. Indian J Pharm Sci 2008;70:614-8.

Wan LS, Choong YL. The effect of excipients on the penetration of

liquid into tablet. Pharm Acta Helv 1986;61:150-5.

Gordon RE, Rashanke TW, Fonner DE, Anderson NR, Banker GS.

Pharmaceutical dosage forms: Tablets. In: Lachman L, Lieberman

HA, Schwartz JB, editors. New York: Marcel Decker; Vol. 2,

p. 245.

Banker GS, Neil RA. Theory and practice of industrial pharmacy.

In: Lachman L, Lieberman AH, Joseph, LK. editors. 3rd ed. Mumbai:

Varghese Publishing House; 1987. p. 297.

Chukwu A, Okpalaezinne P. Preliminary evaluation of cissus root

gum as a binder in sodium salicylate tablet formulations. Drug

Dev Ind Pharm 1989;15:325-30.

Indian Pharmacopoeia, vol 2, Ministry of Health and Family

Welfare, Govt. of India, Controller of Publications, New Delhi:

p. 556, A100-11.

Itiola OA. Characterization of khaya gum as a binder in Paracetamol

tablet formulations. Drug Dev Ind Pharm 2005;28:329-37.



  • There are currently no refbacks.