Aconitum: Need for sustainable exploitation (with special reference to Uttarakhand)

Nidhi Srivastava, Vikas Sharma, Barkha Kamal, Vikash S. Jadon

Abstract


Red Data Book has a long list of many endangered medicinal plants in which genus Aconitum, known as monkshood, wolfsbane, Devil's helmet or blue rocket, belonging to the family Ranunculaceae finds a key position. There are over 250 species of Aconitum.These herbaceous perennial plants are chiefly natives of the mountainous parts of the Northern Hemisphere and are characterised by significant and valuable medicinal properties. Illegal and unscientific extraction from the wild has made the important species of this genus endangered. This review focuses on the importance and medicinal uses of the genus (on the basis of literature cited from different Books and Journals and web, visits to the sites and questionnaires), which have been documented and practiced on the basis of traditional as well as scientific knowledge. The review further presents an insight on the role of conventional and modern
biotechnological methods for the conservation of the said genus, with special reference to Uttarakhand. Further, it is suggested that the policies of government agencies in coordination with the local bodies, scientists, NGOs and end-users be implemented for the sustainable conservation of Aconitum.
Key words: Aconitum, biotechnology, conservation, endangered, medicinal plants, sustainable

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References


Jain SK, Saklani A. Observations on the ethno botany of the Tons

valley region in the Uttarkashi district of the northwest Himalaya,

India. Mt Res Dev 1991;11:157-61.

Jain SK. Dictionary of Indian folk medicine and ethnobotany. New

Delhi: Deep Publications; 1991. p. 331-4.

Kala CP, Dhyani PP, Sajwan BS. Developing the medicinal plant

sector in northern India: Challenges and opportunities. J Ethnobiol

Ethnomed 2006;2:32-53.

Revitalizing traditional herbal therapy by exploring medicinal

plants: A case study of Uttaranchal State in India. Proceedings

of an International Conference on. Indigenous Knowledge:

Transforming the Academy: Penn. State University, Pennsylvania,

USA. 2004;5:15-22

Stein R. Alternative remedies gaining popularity: Majority in U.S.

try some forms, survey finds. The Washington Post Friday, May

, 2004: A01.

Singh DK, Hajara PK. Floristic Diversity. In Changing perspectives

of biodiversity channels by the plant alkaloid lappaconitine (eds

Gujral, G.S. and Sharma, V.), British Council Division, British High

Commission Publ. Wildlife Youth Services, New Delhi, 1996;23-28.

Alam G., P. van de Kop. Promoting the cultivation of medicinal

plants in Uttaranchal, India. Med. Plant Conser. 2005;11: 9-15.

Nautiyal AR, Nautiyal MC, Purohit AN, Editors. Harvesting Herbs

– 2000, Bishen Singh Mahendra Pal Singh. Dehradun, India 1997.

Tandon V. CAMP workshop–plants under threat new list forged.

Medicinal Plants Conservation. Newsl 1996; 2:12-13.

Dhar U, Manjkhola S, Joshi M, Bhatt A, Bisht AK, Joshi M. Current

status and future strategy for development of medicinal plant

sector in Uttaranchal, India. Curr Sci 2002;83:956-64.

Alam G. IPRs, access to seed and related issues: A study of the

Central and North-Eastern Himalayan region. Dehradun: Centre

for Sustainable Development; 2003.

Belt J, Lengkeek A, Vander Zant J. Cultivating a healthy enterprise:

Developing a sustainable medicinal plant chain in Uttaranchal-

India. Amsterdam: KIT Publishers; KIT Bulletin no. 350. 2003.

Available from: http://www.kit.nl/publishers/assets/images/

isbn9068328395_compleet.pdf [last cited on 2003].Alam G, Belt J.

Searching synergy: Stakeholder views on developing a sustainable

medicinal plant chain in Uttaranchal, India. Amsterdam: KIT

Publishers; KIT Bulletin no. 359. 2004. Available from:http://www.

kit.nl/net/KIT_Publicaties_output/showfile.aspx?a=tblFilesandb=

FileIDandc=FileNameandd=TheFileande=605 [last cited on 2004].

Sung Ying-hsing, T’ien Kung k’ai Wu, Sung Ying-Hsing. Published

as Chinese Technology in the seventeenth century. In: E-tu Zen

Sun, Shiou-chuan Sun, translators and annotors. Minneola. New

York: Dover Publications; 1996. p. 267.

Lane B. The encyclopaedia of forensic science. Med Hist 2004;

:53-69.

Bisset NG. Arrow poisons in China. J Ethnopharmacol 1981;4:247-

Moog FP and Karenberg A. Adverse drug reactions and

toxicological reviews. Acute aconitine poisoning. Toxicology in

the Old Testament. 2002;3:151-6.

Kitagawa I, Chen JL, Yoshimura M, Yoshikawa M. Chemical

studies on crude drug processing. II. Aconiti tuber (1). On the

constituents of chuan-wu, the dried tuber of Aconitum carmichaeli

Debeaux. Yakugaku Zasshi 1984; 104:848-57.

Bello-Ramírez AM, Nava-Ocampo AA. The local anesthetic

activity of Aconitum alkaloids can be explained by their structural

properties: A QSAR analysis. Fundam Clin Pharmacol 2004;18:

-61.

Kim HK, Lee HW, Jeon WK. Effects of various processing methods

on the contents of alkaloids in the Cho O (Aconiti Cilliare Tuber).

Kor J Pharmacogn 2002;33:296-300.

Murayama M, Mori T, Bando H, Amiya T. Studies on the

constituents of Aconitum species. IX. The pharmacological

properties of pyro-type aconitine alkaloids, components of

the processed aconite powder 'Kako-bushi-matsu': Analgesic,

anti-inflammatory, and acute toxic activities. J Ethnopharmacol

;35:159-64.

Oyama T, Isono T, Suzuki Y, Hayakawa Y. Antinociceptive effects

of Aconiti tuber and its alkaloids. Am J Chin Med 1994;22:175-82.

Ameri A. The effects of Aconitum alkaloids on the central nervous

system. Prog Neurobiol 1998;56:211-35.

Thatte UM, Rege NN, Phatak SD, Dahanukar SA.The flip side of

Ayurveda. J Postgrad Med 1993;39:179-82.

Mitra SK, Sachan A, Udupa V. Experimental evaluation of Diarex

Vet in lactose induced diarrhea in rats. Indian Vet J 2001;78:212-6.

Jabeen N, Shawl AS, Dar GH, Sultan P. Callus induction and

organogenesis from explants of Aconitum heterophyllum-medicinal

plant. Biotechnology 2006;5:287-91.

Van de Kop P, Alam G, Bart de Steenhuijsen P. Developing a

sustainable medicinal-plant chain in India linking people, markets

and values. In: Ruben R, Slingerland M, Nijhoff H, editors.

Agro-food chains and networks for development. R. Ruben, M.

Slingerland and H. Nijhoff (eds.), Agro-food chains and networks

for development, Springer, 2006. p. 191-202.

Leaman DJ, Salvador S. An international standard for the

sustainable wild collection of medicinal and aromatic plants (ISSCMAP):

Principles, criteria, indicators and means of verification.

Draft- 2, 2005.

Joshi K, Chavan P, Warude D, Patwardhan B. Molecular markers

in herbal technology. Curr Sci 2004; 87:956-64.

Anonymous; 1. Demand study for selected medicinal plants. A

report prepared for the Ministry of Health and Family Welfare,

Govt. of India, Department of Indian System of Medicine and

Homeopathy and World Health Organization. Centre for Research

Planning and Action. New Delhi, 2002.

Maikhuri RK, Nautiyal S, Rao KS. Nanda Devi Jaimandal

aarakshit chetra (Biosphere Reserve) mein auoshadhi paadapon ki

paramparagat krishi taknique. Kosi-Katarmal, Almora: G.B. Pant

Institute of Himalayan Environment and Development; 2002. p. 24.

Schippmann U, Leaman DJ, Cunningham AB. Impact of

cultivation and gathering of medicinal plants on biodiversity:

Global trends and issues. In: Inter-Departmental Working Group

on Biological Diversity for Food and Agriculture ed. Biodiversity

and the ecosystem approach in agriculture, forestry and fisheries:

Satellite event on the occasion of the ninth regular session of the

Commission on Genetic Resources for Food and Agriculture,

Rome, 12-13 October 2002. FAO, Rome, 1-21. Available from: http://

www.ftp://ftp.fao.org/docrep/fao/005/aa010e/AA010E00.pdf [last

cited on 2009 Sep 1].

Shiva MP, Aswal S, Sharma A, Mathur P, Chandra R. Trends

of export and import of minor forest products in India, during

-71 to 1990-91.Centre of minor forest products for rural

development and environmental conservation Dehradun;

HIG 2, No. 8, Indirapuram, General Mahadev Singh Road, P.O.

Majra, Dehradun 248 171. Uttaranchal, INDIA.1996.

Samant SS, Dhar U, Palni LMs. Medicinal plants of Indian

Himalaya: Diversity, Distribution and Potential Values. Gyanodaya

Prakashan, Nainital, 1998. p. 220-32.

Hatano K, Kumara K, Shoyama Y, Mishioka I. Clonal multiplication

of Aconitum carmichaeli by tip-tissue culture technique. Planta

Medica 1998;54:152-5.

Shiping C, Shan SJ, Tanaka H, Shoyama Y. Effects of culture

temperature on microtuber formation of Aconitum carmichaelii

debx. and aconitine type Alkaloid contents. Biotronics 1998;27:

-20.

Batygina TB. Polymorphism of sexual and somatic embryos as

manifestation of their developmental parallelism under natural

conditions and in tissue culture. In: Srivastava PS, Narula A, and

Srivastava S [eds.], Plant biotechnology and molecular markers,.

Anamaya Publishers, New Delhi. 2004: 43–59

Kuniyal CP, Rajsekaran C, Prasad P, Bhadula SK. Propagation of

a threatened medicinal herb Aconitum atrox (Bruhl) Muk. through

tuber segments. Plant Genet Resour 2006;135:59-62.

Pandey H, Nandi SK, Nadeem M, Palni LM. Chemical stimulation

of seed germination in Aconitum heterophyllum Wall and A. balfouriiStapf: Important Himalayan species of medicinal value. Seed

Science and Technology. 2000;28:39-48.

Beigh SY, Nawchoo IA, Iqbal M. Cultivation and conservation of

Aconitum heterophyllum: A critically endangered medicinal herb

of the northwest Himalayas. J Herbs Spices Med Plants 2005;

:47-56.

Pandey S, Khushwaha R, Prakash O, Bhattacharya A, Ahuja PS.

Ex-situ conservation of Aconitum heterophyllum wall, an endangered

medicinal plant of the Himalaya through mass propagation and

its effect on growth and alkaloid content. Plant Genet Resour

;3:127-35.

Prasad P. Impact of cultivation on active constituents of the medicinal

plants Aconitum heterophyllum and Podophyllum hexandrum. Plant

Genet Resour Newsl 2000;124:33-5.

Gao LM, Yan LY, He HY, Wei XM. Norditerpenoid alkaloids from

Aconitum spicatum. J Integr Plant Biol 2005;48:364-9.

Tang Q, Yang C, Ye W, Liu J, Zhao S. Preparative isolation and

purification of bioactive constituents from Aconitum coreanum

by high-speed counter-current chromatography coupled with

evaporative light scattering detection. J Chromatogr 2007;11:203-7.

Lyu HN, Kwak HY, Lee DY, Kim KT, Kim SY, Baek NI. Isolation

of flavanoids from processed aconiti tuber. J Appl Biol Chem

;51:165-8.

Ahmad M, Ahmad W, Ahmad M, Zeeshan M, Obaidullah,

Shaheen F. Norditerpenoid alkaloids from the roots of Aconitum

heterophyllum wall with antibacterial activity. J Enzyme Inhib Med

Chem 2008;23:1018-22.

Nisar M, Obaidullah, Ahmad M, Wadood N, Lodhi MA, Shaheen F,

et al. New diterpenoid alkaloids from Aconitum heterophyllum wall:

Selective butyrylcholinestrase inhibitors. J Enzyme Inhib Med

Chem 2009;24:47-51.

Wang SY, Wang GK. Voltage-gated sodium channels as

primary targets of diverse lipid-soluble neurotoxins. Cell Signal

;15:151-9.

Fu M, Wu M, Qiao Y, Wang Z. Toxicological mechanisms of

Aconitum alkaloids. Pharmazie 2006;61: 735-41.

Anwar S, Ahmad B, Muhammad S, Nazar-ul-Islam and

Gul A. Biological and pharmacological properties of Aconitum

chasmanthum. J Biol Sci 2003;3(11): 989-993

Fico G, Spada A, Braca A, Agradi E, Morelli I, Tome F. RAPD

analysis and flavanoid composition of Aconitum as an aid for

taxonomic discrimination. Biochem Syst Ecol 2003;31:293-301.

Luo Y, Zhang FM, Yang QE. Phylogeny of Aconitum subgenus

Aconitum (Ranunculaceae) inferred from ITS sequences. Plant

Syst Evol 2005;252:11-25.

Mitka J, Sutkowska A, Ilnicki T, Joachimiak AJ. Reticulate evolution

of high alpine aconitum (Ranunculaceae) in the eastern Sudetes

and western Carpathians (Central Europe). Acta Biol Crac Ser

Bot 2007;49:15-26.




DOI: http://dx.doi.org/10.22377/ijgp.v4i4.151

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