Diuretic activity of extracts of Centratherum anthelminticum

B. C. Koti, A. Purnima


In the present study petroleum ether, chloroform and alcohol extracts of Centratherum anthelminticum (L.) Kuntze (family: Asteraceae) seeds (200 mg/kg b.w., p.o.) were tested for diuretic activity. Th e animals were grouped into fi ve of six animals each. All the animals received priming dose of 0.9% sodium chloride solution (25 ml/kg b.w.). Th e fi rst group served as control and the second group received the standard drug spiranolactone (20 mg/kg body weight) in 0.9% sodium chloride solution. Th e other three groups received petroleum ether, chloroform, and alcohol extracts of C. anthelminticum seeds in a dose of 200 mg/kg body weight suspended in 0.9%
sodium chloride solution (p.o.). Urine volume was recorded for all the groups for 5 h. Th e highest diuretic activity was presented by
alcohol extract followed by that of chloroform, petroleum ether extract has no signifi cant diuretic activity. Alcohol and chloroform
extracts signifi cantly decreased K+ excretion. We observed a potent diuretic and electrolyte excretion activity of chloroform and
alcohol extracts of C. anthelminticum seeds. Th ese fi ndings suggest the possible traditional use of this plant in hypertension as diuretics are used in the management of hypertension.
Key words: Centratherum anthelminticum, diuretic activity, electrolyte excretion, hypertension, spiranolactone

Full Text:



Agunu A, Abdurahman EM, Andrew GO, Muhammed Z. Diuretic

activity of the stem-bark extracts of Steganotaenia araliaceahoehst.

J Ethnopharmcol 2005;96:471-5.

Agus ZS, Goldberg M. Role of antidiuretic hormone in the

abnormal water diuresis of anterior hypopituitarism in man. J

Clin Invest 1971;50:1478-89.

Stookey JD. The diuretic eff ects of alcohol and caff eine and total

water intake misclassiÞ cation. Eur J Epidemiol 1999;15:181-8.

Rang HP, Dale MM, Ritt er JM. In: Text book of Pharmacology. 2nd

ed. Churchill Livingstone; 1994. p. 428-38.

Kirtikar KR, Basu BD. Indian Medicinal Plants, 4th ed. Vol II.

International Book Distributors; Dehradun: 1975. p. 1325-27.

Chopra RN, Chopra IC, Handa KL, Kapur LD. Indigenous Drugs

of India, 1st ed. Calcutt a: Dhur DK of Academic Publisher; 1994.

p. 434-5.

Kokate CK, Purohirt AR, Gokhale CB. Pharmacognosy. 27th ed.

Nirali Prakashan; 2004. p. 344.

Finar IL. Organic chemistry- stereochemistry and the chemistry

of natural products. 5th ed. Singapore: Pearson Education Ltd;

p. 518.

Rao VS, Fonteles MC. Eff ects of nifedipine on renal responses to

several diuretic agents in rats. J Pharm Pharmacol 1991;43:741-3.

Vogel GH, Vogel WH. Drug Discovery and Evaluation:

Pharmacological Assays. Germany: Springer-Verlag Berlin

Heidelberg; 1997. p. 323-4.

Lipschitz WL, Hadidian, Kerpcer A. Bioassay of Diuretics. J

Pharmacol Exp and Ther 1943;79:97-110.

Guyton AC. Blood pressure control-special role of the kidneys and

body ß uids. Science 1991;252:1813-6.

Haloui M, Louedec L, Michel JB, Lyoussi B. Experimental diuretic

eff ects of Rosmarinus offi cinalis and Centaurium erythraea. J

Ethnopharmacol 2000;71:465-72.

DOI: https://doi.org/10.22377/ijgp.v2i4.14


  • There are currently no refbacks.