Evaluation of protective role of N-methyl-D-aspartate receptor antagonist against Parkinson’s model(s) in rat

Abstract

Aim: The objectives of the present research were ssto observe the effect of N-methyl-D-aspartate (NMDA) receptor antagonist on Parkinson model(s) in rats and to compare the efficacy of NMDA receptor antagonist with standard antiparkinson drug. Materials and Methods: Albino rats were divided into five experimental groups of six each. 24 animals except normal and acute dose of haloperidol (1 mg/kg) were administered intraperitoneally for induction of catalepsy. Six animals received saline 0.9% NaCl and served as normal saline. On the 20th day, catalepsy was evaluated by reported instruments. Levodopa (150mg/kg) was used as standard drug and kynurenic acid (50 mg/kg and 100 mg/kg) was used as test drug. Different instrument utilized in the study was catalepsy bar test, actophotometer, and rotarod. Results and Discussions: The results showed that acute administration of kynurenic acid (50 mg/kg and 100 mg/kg) significantly reduced catalepsy, grooming and significantly increased motor coordination, locomotor activity. Conclusion: It was concluded from the study that kynurenic acid ameliorates the symptoms of Parkinson’s disease in rats.